Could a simple probe placement change improve GERD diagnosis for millions?
NCT ID NCT07716592
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study tests whether placing a pH monitoring probe closer to the stomach (1 cm above the squamocolumnar junction) instead of the standard 6 cm position improves detection of acid reflux in women and people with lower body weight. Participants receive two probes simultaneously during a routine diagnostic endoscopy and wear them for 96 hours while recording symptoms. The goal is to see if the closer placement catches reflux episodes that the standard position misses, potentially leading to more accurate GERD diagnosis in these groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bravo pH monitoring with dual probe placement (standard 6 cm above SCJ and experimental 1 cm above SCJ)
- What this could lead to
- If successful, this could lead to more accurate GERD diagnosis for women and people with lower body weight, reducing missed cases.
- What could go wrong
- This is a small, early-stage study focused on diagnostic accuracy, not treatment. The experimental probe placement may not improve detection and could cause discomfort.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The University o Chicago
Chicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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