New study probes muscle fibrosis in swallowing disorder

NCT ID NCT04641702

Recruiting now Knowledge-focused Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how muscle scarring in the esophagus relates to swallowing problems in people with achalasia. Researchers will use a special probe and muscle biopsies to measure scarring and muscle function. The goal is to better understand the disease so doctors can treat it earlier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atropine
What this could lead to: If successful, this could lead to earlier diagnosis and better treatments for achalasia by linking muscle scarring to esophageal function.
What could go wrong: This is an early-phase observational study with only 80 participants, so results may not apply to all patients. The atropine challenge may cause temporary side effects like dry mouth or blurred vision.

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Conditions

The condition(s) this trial relates to.

achalasia dyskinesia of esophagus Esophageal Achalasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACHALASIA

Contacts and locations

Locations

Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States

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