ACHALASIA

This study follows 200 adults with achalasia who undergo a procedure called POEM (peroral endoscopic myotomy). The goal is to see if the procedure safely reduces chest pain and swallowing problems. Researchers will review past and future patient records up to 180 days after the p…

This study tests whether giving anti-viral medication to kill the shingles virus (VZV) living in the gut can improve symptoms of achalasia, a severe swallowing disorder. Researchers will enroll 40 adults with achalasia and measure changes in swallowing, pain, and weight. The goal…

This study compares two methods of preventing bleeding during a procedure called POEM, used to treat swallowing disorders. The standard method uses carbon dioxide gas, while the new method uses water to help seal blood vessels. Researchers will enroll 120 adults to see if the wat…

This study tests a new device called SpydrBlade Flex for a procedure that helps people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing difficult. The device uses radiofrequency and microwave energy to cut muscle. Researchers will check if…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This study looks at how safe and effective a new device, the Speedboat UltraSlim™, is when used for a surgery called POEM in people with achalasia or other throat muscle problems. The surgery is already standard care, and researchers will track symptom improvement and any side ef…

This study looks at 200 adults to compare acid reflux-related damage in two groups: people who had a procedure called POEM for achalasia (a swallowing disorder) and people without any swallowing problems. Researchers will use endoscopy and acid monitoring to see if the pattern of…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study looks at how muscle scarring in the esophagus relates to swallowing problems in people with achalasia. Researchers will use a special probe and muscle biopsies to measure scarring and muscle function. The goal is to better understand the disease so doctors can treat it…

This study looks at whether a special green dye (indocyanine green) can help surgeons see and fix leaks during laparoscopic Heller-Dor surgery for achalasia, a condition that makes swallowing difficult. About 70 adults with type I or II achalasia will take part. The dye is inject…