Smaller incision, same relief? new trial tests less invasive POEM for achalasia

NCT ID NCT07293650

Recruiting now Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 28, 2026 · Updated 5 times

Summary

This study compares a shorter muscle cut (4-5 cm) during a procedure called POEM to the standard longer cut (8-10 cm) for people with certain swallowing disorders. The goal is to see if the shorter cut works just as well at relieving symptoms like trouble swallowing and chest pain, while possibly causing fewer side effects. About 372 adults with type I or II achalasia or related conditions will participate and be followed for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Per-Oral Endoscopic Myotomy (POEM) procedure
What this could lead to: If successful, this could mean a less invasive, safer procedure for people with swallowing disorders, reducing side effects while maintaining symptom relief.
What could go wrong: This is a Phase 3 trial, but it's still possible the shorter cut won't work as well as the standard one, or that benefits vary by patient. Side effects like reflux may still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

achalasia Esophageal Achalasia idiopathic achalasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EGJ OUTFLOW OBSTRUCTION WITHOUT SPASTIC/HYPERCONTRACTILE FEATURES TYPE I ACHALASIA TYPE II ACHALASIA

Contacts and locations

Locations

Adventist Health System/Sunbelt, Inc
NOT_YET_RECRUITING

Orlando, Florida, 32803, United States
Atrium Health/Wake Forest
RECRUITING

Charlotte, North Carolina, 28204, United States
Baylor Scott & White Health
NOT_YET_RECRUITING

Dallas, Texas, 75204, United States
Case Western Reserve University
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
Emory University
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Johns Hopkins University
NOT_YET_RECRUITING

Baltimore, Maryland, 21218, United States
Mayo Clinic Arizona
NOT_YET_RECRUITING

Scottsdale, Arizona, 85259, United States
MetroHealth Medical Center
RECRUITING

Cleveland, Ohio, 44109, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
University of California San Diego
NOT_YET_RECRUITING

La Jolla, California, 92093, United States
University of Colorado Denver
NOT_YET_RECRUITING

Denver, Colorado, 80217, United States
University of Florida
NOT_YET_RECRUITING

Gainesville, Florida, 32611, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University
NOT_YET_RECRUITING

St Louis, Missouri, 63130, United States
Weill Cornell Medical College
NOT_YET_RECRUITING

New York, New York, 10065, United States

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