Smaller incision, same relief? new trial tests less invasive POEM for achalasia
NCT ID NCT07293650
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares a shorter muscle cut (4-5 cm) during a procedure called POEM to the standard longer cut (8-10 cm) for people with certain swallowing disorders. The goal is to see if the shorter cut works just as well at relieving symptoms like trouble swallowing and chest pain, while possibly causing fewer side effects. About 372 adults with type I or II achalasia or related conditions will participate and be followed for two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Per-Oral Endoscopic Myotomy (POEM) procedure
What this could lead to
If successful, this could mean a less invasive, safer procedure for people with swallowing disorders, reducing side effects while maintaining symptom relief.
What could go wrong
This is a Phase 3 trial, but it's still possible the shorter cut won't work as well as the standard one, or that benefits vary by patient. Side effects like reflux may still occur.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Adventist Health System/Sunbelt, Inc
NOT_YET_RECRUITINGOrlando, Florida, 32803, United States
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Baylor Scott & White Health
NOT_YET_RECRUITINGDallas, Texas, 75204, United States
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Case Western Reserve University
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
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Emory University
NOT_YET_RECRUITINGAtlanta, Georgia, 30322, United States
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Johns Hopkins University
NOT_YET_RECRUITINGBaltimore, Maryland, 21218, United States
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Mayo Clinic Arizona
NOT_YET_RECRUITINGScottsdale, Arizona, 85259, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of California San Diego
NOT_YET_RECRUITINGLa Jolla, California, 92093, United States
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University of Colorado Denver
NOT_YET_RECRUITINGDenver, Colorado, 80217, United States
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University of Florida
NOT_YET_RECRUITINGGainesville, Florida, 32611, United States
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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Washington University
NOT_YET_RECRUITINGSt Louis, Missouri, 63130, United States
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Weill Cornell Medical College
NOT_YET_RECRUITINGNew York, New York, 10065, United States