Esophageal leukoplakia
MONDO:0004697A rare condition that usually affects the middle-to-distal esophagus in middle-aged and elderly people. There is usually a history of tobacco smoking or alcohol intake. Dysphagia is the presenting symptom. Morphologically, the lesions are well-demarcated and are characterized by epithelial hyperplasia, thickened basal layer, prominent granular cell layer, and hyperorthokeratosis. In a minority of patients this condition is associated with adjacent high-grade squamous dysplasia and/or squamous cell carcinoma.
Also known as: esophageal epidermoid metaplasia, esophageal leukoplakia, esophageal leukoplakia (disease), esophagus leukoplakia, leukoplakia of esophagus, leukoplakia of oesophagus, leukoplakia of the esophagus, leukoplakia of the oesophagus
20 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Botox injection could replace surgery for Post-Esophagectomy stomach issues
Disease control Recruiting nowThis study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…
Phase: PHASE2, PHASE3 • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Simple blood test could spot cancer early
Diagnosis Recruiting nowThis study is testing a new blood test called PanTum Detect to see how well it can find early signs of cancer or pre-cancer. The test looks for certain markers in immune cells. Researchers will compare the blood test results with standard PET/CT scans in 134 adults—half with susp…
Phase: NA • Sponsor: Comenius University • Aim: Diagnosis
Last updated Jun 27, 2026 08:11 UTC
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AI tool aims to sharpen esophageal cancer staging
Diagnosis Recruiting nowThis study tests an artificial intelligence system that assists doctors in determining how deep early esophageal cancer has spread, using endoscopic ultrasound images. The goal is to improve the accuracy of preoperative staging, which helps guide treatment decisions. Researchers …
Phase: NA • Sponsor: Fujian Provincial Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:00 UTC
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Swallow a tiny magnet: painless camera could replace endoscopy
Diagnosis Recruiting nowThis study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…
Sponsor: Bács-Kiskun County Teaching Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Scientists launch massive tumor repository to unlock cancer secrets
Knowledge-focused Recruiting nowThis study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jul 03, 2026 23:00 UTC
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NIH launches massive GI data bank to fuel future discoveries
Knowledge-focused Recruiting nowThis study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study aims to sharpen diagnosis of swallowing disorders
Knowledge-focused Recruiting nowThis study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Massive cancer gene mapping project aims to unlock new treatments
Knowledge-focused Recruiting nowThis study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…
Sponsor: Avera McKennan Hospital & University Health Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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5000 volunteers help hunt for hidden cancer clues
Knowledge-focused Recruiting nowThis study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Robot vs. laparoscopic: which pancreas surgery is better?
Knowledge-focused Recruiting nowThis study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …
Phase: NA • Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:56 UTC