New cocktail of drugs could shrink stomach tumors before surgery

NCT ID NCT07069712

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests several new drug combinations given before and after surgery for stomach or esophageal cancer. About 100 people with resectable tumors will receive these treatments to see if they are safe and can shrink or eliminate the cancer. The goal is to improve outcomes by attacking the cancer more effectively before surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD0901, Rilvegostomig, Trastuzumab Deruxtecan, Capecitabine, 5-Fluorouracil, FLOT chemotherapy
What this could lead to: If successful, this could lead to better treatment options before surgery for stomach cancer, potentially improving survival and reducing recurrence.
What could go wrong: This is an early-phase trial with only 100 participants, so results may not apply to everyone. The new drug combinations may cause side effects or not work better than current treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal adenocarcinoma gastric adenocarcinoma gastric neoplasm gastroesophageal adenocarcinoma gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL ADENOCARCINOMA

Contacts and locations

Locations

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Newark, Delaware, 19713, United States
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Washington D.C., District of Columbia, 20007, United States
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Fairway, Kansas, 66205, United States
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North Shores, Michigan, 49444, United States
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NOT_YET_RECRUITING

New York, New York, 10032, United States
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New York, New York, 10065, United States
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NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
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SUSPENDED

Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Beijing, 100142, China
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Changchun, 130021, China
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Changzhi, 046000, China
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Chengdu, 610041, China
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Chengdu, 610042, China
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NOT_YET_RECRUITING

Fuzhou, 350014, China
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Hangzhou, 310003, China
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Hangzhou, 310014, China
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Kunming, 650118, China
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Qingdao, 266003, China
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Shanghai, 200025, China
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WITHDRAWN

Shijiazhuang, 050020, China
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Tbilisi, 0112, Georgia
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Tbilisi, 0114, Georgia
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Tbilisi, 0144, Georgia
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Tbilisi, 0159, Georgia
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Florence, 50134, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Milan, 20162, Italy
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Modena, 41124, Italy
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Pisa, 56100, Italy
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Rozzano, 20089, Italy
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Udine, 33100, Italy
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Vicenza, 36100, Italy
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hidaka-shi, 350-1298, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Nagoya, 464-8681, Japan
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Osaka, 541-8567, Japan
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Osaka, 558-8558, Japan
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Suita-shi, 565-0871, Japan
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Yokohama, 241-8515, Japan
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Bialystok, 15-027, Poland
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Warsaw, 02-034, Poland
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Elche, 03203, Spain
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Madrid, 28007, Spain
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Málaga, 29010, Spain
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Ourense, 32005, Spain
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Oviedo, 33011, Spain
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Santander, 39008, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 80756, Taiwan
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Tainan, 704, Taiwan
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Taipei, 11217, Taiwan
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Taoyuan, 33305, Taiwan
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WITHDRAWN

Adapazarı, 54100, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Fatih-Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Bristol, BS2 8ED, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Headington, OX3 7LJ, United Kingdom
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NOT_YET_RECRUITING

London, E1 1BB, United Kingdom
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Norwich, NR4 7UY, United Kingdom

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