New hope for advanced stomach cancer: experimental drug combos enter human trials

NCT ID NCT06445972

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a standard targeted therapy plus chemotherapy. The goal is to see if the new combinations are safe and can shrink tumors or slow cancer growth.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Asan Medical Center-Department of Oncology ( Site 7901)

    RECRUITING

    Seoul, 05505, South Korea

  • Azienda Ospedaliero Universitaria Pisana ( Site 7206)

    RECRUITING

    Pisa, Tuscany, 56126, Italy

  • Beijing Cancer hospital-Digestive Oncology ( Site 7500)

    RECRUITING

    Beijing, Beijing Municipality, 100142, China

  • Bradford Hill Norte ( Site 8407)

    RECRUITING

    Antofagasta, 1263521, Chile

  • Bradfordhill-Clinical Area ( Site 8401)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • CIC. ( Site 7100)

    RECRUITING

    Lille, Nord, 59037, France

  • Centre Hospitalier Régional Universitaire de Brest - Hôpital-Institut de cancérologie et hématologi ( Site 7104)

    RECRUITING

    Brest, Finistere, 29200, France

  • Centro de Investigación del Maule ( Site 8408)

    RECRUITING

    Talca, Maule Region, 3481349, Chile

  • Centro de Oncología de Precisión-Oncology ( Site 8404)

    RECRUITING

    Santiago, Region M. de Santiago, 7560908, Chile

  • China Medical University Hospital ( Site 8007)

    RECRUITING

    Taichung, 404332, Taiwan

  • Clínica Puerto Montt ( Site 8409)

    RECRUITING

    Port Montt, Los Lagos Region, 5500243, Chile

  • Clínica UC San Carlos de Apoquindo ( Site 8405)

    RECRUITING

    Santiago, Region M. de Santiago, 7620002, Chile

  • Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 8907)

    COMPLETED

    New York, New York, 10032, United States

  • FALP-UIDO ( Site 8400)

    RECRUITING

    Santiago, Region M. de Santiago, 7500921, Chile

  • Facharztzentrum Eppendorf-Facharztzentrum Eppendorf ( Site 8807)

    RECRUITING

    Hamburg, 20249, Germany

  • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 7200)

    RECRUITING

    Milan, Lombardy, 20133, Italy

  • Fudan University Shanghai Cancer Center ( Site 7513)

    RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Hematology-Oncology Associates of Central NY, P.C. ( Site 8925)

    RECRUITING

    East Syracuse, New York, 13057, United States

  • Henan Cancer Hospital ( Site 7504)

    RECRUITING

    Zhengzhou, Henan, 450000, China

  • Hospital Nossa Senhora da Conceição ( Site 8301)

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hôpitaux Universitaires de Genève (HUG) ( Site 8701)

    RECRUITING

    Geneva, Canton of Geneva, 1211, Switzerland

  • IBCC - Instituto Brasileiro de Controle do Câncer ( Site 8304)

    RECRUITING

    São Paulo, São Paulo, 03102-002, Brazil

  • ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 8300)

    RECRUITING

    São Paulo, 01246-000, Brazil

  • IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 7207)

    RECRUITING

    Meldola, Emilia-Romagna, 47014, Italy

  • Kantonsspital Graubünden-Medizin ( Site 8700)

    RECRUITING

    Chur, Kanton Graubünden, 7000, Switzerland

  • Liga Norte Riograndense Contra o Câncer ( Site 8303)

    RECRUITING

    Natal, Rio Grande do Norte, 59062-000, Brazil

  • NCT-Department of Medical Oncology ( Site 8809)

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • National Cheng Kung University Hospital ( Site 8001)

    RECRUITING

    Tainan, 704, Taiwan

  • National Taiwan University Hospital-Oncology ( Site 8000)

    RECRUITING

    Taipei, 10048, Taiwan

  • Norton Cancer Institute - Downtown ( Site 8900)

    COMPLETED

    Louisville, Kentucky, 40202, United States

  • Oslo universitetssykehus, Radiumhospitalet ( Site 8501)

    RECRUITING

    Oslo, 0379, Norway

  • Ospedale San Raffaele-Oncologia Medica ( Site 7202)

    RECRUITING

    Milan, 20132, Italy

  • Pitie Salpetriere University Hospital-Hepato-Gastro-Enterology ( Site 7102)

    RECRUITING

    Paris, Île-de-France Region, 75013, France

  • Samsung Medical Center-Division of Hematology/Oncology ( Site 7900)

    RECRUITING

    Seoul, 06351, South Korea

  • Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 7510)

    RECRUITING

    Hangzhou, Zhejiang, 310016, China

  • Taipei Veterans General Hospital ( Site 8005)

    RECRUITING

    Taipei, 112, Taiwan

  • The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Site 7501)

    RECRUITING

    Fuzhou, Fujian, 350025, China

  • The Cancer and Hematology Centers ( Site 8912)

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • The First Affiliated Hospital of Nanchang University ( Site 7514)

    RECRUITING

    Nanchang, Jiangxi, 330000, China

  • The First Affiliated hospital of Xiamen University ( Site 7503)

    RECRUITING

    Xiamen, Fujian, 361003, China

  • UCLA Hematology/Oncology - Santa Monica ( Site 8905)

    RECRUITING

    Los Angeles, California, 90404, United States

  • UPMC Hillman Cancer Center-UPMC ( Site 8904)

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 8806)

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Duesseldorf-Gastroenterology, Hepatology and Infectiology ( Site 8802)

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 8927)

    RECRUITING

    Tucson, Arizona, 85719, United States

  • University of Texas MD Anderson Cancer Center ( Site 8920)

    RECRUITING

    Houston, Texas, 77030, United States

  • Xinjiang Medical University Cancer Hospital - Urumqi ( Site 7506)

    RECRUITING

    Ürümqi, Xinjiang, 841100, China

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