New hope for advanced stomach cancer: experimental drug combos enter human trials
NCT ID NCT06445972
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a standard targeted therapy plus chemotherapy. The goal is to see if the new combinations are safe and can shrink tumors or slow cancer growth.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Asan Medical Center-Department of Oncology ( Site 7901)
RECRUITINGSeoul, 05505, South Korea
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Azienda Ospedaliero Universitaria Pisana ( Site 7206)
RECRUITINGPisa, Tuscany, 56126, Italy
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Beijing Cancer hospital-Digestive Oncology ( Site 7500)
RECRUITINGBeijing, Beijing Municipality, 100142, China
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Bradford Hill Norte ( Site 8407)
RECRUITINGAntofagasta, 1263521, Chile
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Bradfordhill-Clinical Area ( Site 8401)
RECRUITINGSantiago, Region M. de Santiago, 8420383, Chile
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CIC. ( Site 7100)
RECRUITINGLille, Nord, 59037, France
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Centre Hospitalier Régional Universitaire de Brest - Hôpital-Institut de cancérologie et hématologi ( Site 7104)
RECRUITINGBrest, Finistere, 29200, France
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Centro de Investigación del Maule ( Site 8408)
RECRUITINGTalca, Maule Region, 3481349, Chile
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Centro de Oncología de Precisión-Oncology ( Site 8404)
RECRUITINGSantiago, Region M. de Santiago, 7560908, Chile
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China Medical University Hospital ( Site 8007)
RECRUITINGTaichung, 404332, Taiwan
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Clínica Puerto Montt ( Site 8409)
RECRUITINGPort Montt, Los Lagos Region, 5500243, Chile
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Clínica UC San Carlos de Apoquindo ( Site 8405)
RECRUITINGSantiago, Region M. de Santiago, 7620002, Chile
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Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 8907)
COMPLETEDNew York, New York, 10032, United States
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FALP-UIDO ( Site 8400)
RECRUITINGSantiago, Region M. de Santiago, 7500921, Chile
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Facharztzentrum Eppendorf-Facharztzentrum Eppendorf ( Site 8807)
RECRUITINGHamburg, 20249, Germany
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Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 7200)
RECRUITINGMilan, Lombardy, 20133, Italy
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Fudan University Shanghai Cancer Center ( Site 7513)
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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Hematology-Oncology Associates of Central NY, P.C. ( Site 8925)
RECRUITINGEast Syracuse, New York, 13057, United States
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Henan Cancer Hospital ( Site 7504)
RECRUITINGZhengzhou, Henan, 450000, China
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Hospital Nossa Senhora da Conceição ( Site 8301)
RECRUITINGPorto Alegre, Rio Grande do Sul, 91350-200, Brazil
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Hôpitaux Universitaires de Genève (HUG) ( Site 8701)
RECRUITINGGeneva, Canton of Geneva, 1211, Switzerland
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IBCC - Instituto Brasileiro de Controle do Câncer ( Site 8304)
RECRUITINGSão Paulo, São Paulo, 03102-002, Brazil
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ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 8300)
RECRUITINGSão Paulo, 01246-000, Brazil
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 7207)
RECRUITINGMeldola, Emilia-Romagna, 47014, Italy
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Kantonsspital Graubünden-Medizin ( Site 8700)
RECRUITINGChur, Kanton Graubünden, 7000, Switzerland
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Liga Norte Riograndense Contra o Câncer ( Site 8303)
RECRUITINGNatal, Rio Grande do Norte, 59062-000, Brazil
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NCT-Department of Medical Oncology ( Site 8809)
RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
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National Cheng Kung University Hospital ( Site 8001)
RECRUITINGTainan, 704, Taiwan
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National Taiwan University Hospital-Oncology ( Site 8000)
RECRUITINGTaipei, 10048, Taiwan
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Norton Cancer Institute - Downtown ( Site 8900)
COMPLETEDLouisville, Kentucky, 40202, United States
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Oslo universitetssykehus, Radiumhospitalet ( Site 8501)
RECRUITINGOslo, 0379, Norway
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Ospedale San Raffaele-Oncologia Medica ( Site 7202)
RECRUITINGMilan, 20132, Italy
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Pitie Salpetriere University Hospital-Hepato-Gastro-Enterology ( Site 7102)
RECRUITINGParis, Île-de-France Region, 75013, France
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Samsung Medical Center-Division of Hematology/Oncology ( Site 7900)
RECRUITINGSeoul, 06351, South Korea
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Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 7510)
RECRUITINGHangzhou, Zhejiang, 310016, China
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Taipei Veterans General Hospital ( Site 8005)
RECRUITINGTaipei, 112, Taiwan
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The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Site 7501)
RECRUITINGFuzhou, Fujian, 350025, China
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The Cancer and Hematology Centers ( Site 8912)
RECRUITINGGrand Rapids, Michigan, 49503, United States
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The First Affiliated Hospital of Nanchang University ( Site 7514)
RECRUITINGNanchang, Jiangxi, 330000, China
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The First Affiliated hospital of Xiamen University ( Site 7503)
RECRUITINGXiamen, Fujian, 361003, China
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UCLA Hematology/Oncology - Santa Monica ( Site 8905)
RECRUITINGLos Angeles, California, 90404, United States
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UPMC Hillman Cancer Center-UPMC ( Site 8904)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 8806)
RECRUITINGDresden, Saxony, 01307, Germany
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Universitaetsklinikum Duesseldorf-Gastroenterology, Hepatology and Infectiology ( Site 8802)
RECRUITINGDüsseldorf, North Rhine-Westphalia, 40225, Germany
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University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 8927)
RECRUITINGTucson, Arizona, 85719, United States
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University of Texas MD Anderson Cancer Center ( Site 8920)
RECRUITINGHouston, Texas, 77030, United States
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Xinjiang Medical University Cancer Hospital - Urumqi ( Site 7506)
RECRUITINGÜrümqi, Xinjiang, 841100, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI-Guided home training boost recovery from gastric cancer surgery?
- Can a new drug combo revive Immunotherapy's power against resistant tumors?
- A high-tech camera may take the guesswork out of spotting a dangerous surgery complication
- Can switching cancer therapy early extend life in stomach cancer?
- Blood test score may flag High-Risk esophageal surgery patients
- Can a new drug combo shrink Hard-to-Treat tumors?