New procedure could reduce GERD symptoms without surgery
NCT ID NCT05570448
First seen Mar 16, 2026 · Last updated Jun 23, 2026 · Updated 21 times
Summary
This study tests a new endoscopic procedure called anti-reflux mucosal ablation (ARAT) for people with chronic GERD. The procedure uses argon plasma coagulation to treat the lining of the stomach near the esophagus. 36 participants will be randomly assigned to receive either the real procedure or a sham procedure. The goal is to see if ARAT improves quality of life and reduces the need for daily acid-reducing medications.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kansas City VA Hospital
RECRUITINGKansas City, Missouri, 64128, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Anti-reflux mucosal ablation using argon plasma coagulation
What this could lead to
If successful, this procedure could offer a non-surgical option to reduce GERD symptoms and dependence on daily acid-reducing medications.
What could go wrong
This is a small, early-stage trial with only 36 participants. The procedure may not work better than a sham, and there are risks like bleeding or stricture.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.