New hope for toddlers with esophagus inflammation: dupilumab trial launches

NCT ID NCT07112378

Recruiting now Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 5 times

Summary

This study tests the drug dupilumab in children as young as 6 months who have active eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus and can make eating difficult. The goal is to see if the drug is safe and effective over 24 weeks. About 20 children will participate, receiving one of two dose regimens.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dupilumab (Dupixent)
What this could lead to: If successful, this could provide a treatment option for young children with EoE, helping reduce inflammation and improve feeding and growth.
What could go wrong: This is a small, early-phase study with only 20 children, so results may not apply broadly. Side effects are possible, and the drug may not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

eosinophilic esophagitis esophageal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC ESOPHAGITIS (EOE)

Contacts and locations

Locations

Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Cook Children's Medical Center
RECRUITING

Fort Worth, Texas, 76104, United States
GI Care for Kids LLC
RECRUITING

Atlanta, Georgia, 30342, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin, Children's Hospital of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Phoenix Childrens Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
University of California San Francisco (UCSF)
RECRUITING

San Francisco, California, 94143, United States
University of North Carolina, Bioinformatics Building
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10065, United States

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