New drug targets Hard-to-Treat cancers with genetic weakness

NCT ID NCT07109726

Recruiting now Disease control Sponsor: Terremoto Biosciences Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive the drug, and researchers will monitor side effects and how well the cancer responds.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cervical cancer endometrial cancer endometrium adenocarcinoma endometrium neoplasm esophageal squamous cell carcinoma head and neck squamous cell carcinoma hormone receptor-positive breast cancer neoplasm ovarian cancer Squamous Cell Carcinoma of Head and Neck squamous cell lung carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER CERVICAL CANCER ENDOMETRIAL CANCER ESOPHAGEAL SQUAMOUS CELL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA LUNG SQUAMOUS CELL CARCINOMA OVARIAN CANCER SOLID TUMOR

Contacts and locations

Show contact details

Locations

Carolina BioOncology Institute
RECRUITING

Huntersville, North Carolina, 28078, United States

Contact Email: •••••@•••••
Florida Cancer Specialists - Lake Nona
RECRUITING

Orlando, Florida, 32827, United States
Froedtert & MCW Cancer Center
RECRUITING

Milwaukee, Wisconsin, 53226, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02144, United States
Mayo Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Email: •••••@•••••
NEXT Oncology
RECRUITING

Austin, Texas, 78229, United States
NEXT Oncology
RECRUITING

Fairfax, Virginia, 22031, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68130, United States
PanOncology Trials
RECRUITING

San Juan, 00935, Puerto Rico

Contact Email: •••••@•••••
START Center for Cancer Research
RECRUITING

San Antonio, Texas, 78229, United States
START Center for Cancer Research
RECRUITING

West Valley City, Utah, 84119, United States
Sarah Cannon Nashville
RECRUITING

Nashville, Tennessee, 37203, United States
UH Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
Washington Univ. School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.