Battle of the scopes: which technique best wipes out Barrett's lesions?
NCT ID NCT05276791
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This trial compares two endoscopic procedures—endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)—for removing visible precancerous lesions in people with Barrett's esophagus. About 331 adults with Barrett's esophagus and early-stage abnormal tissue will be randomly assigned to one of the two techniques. The goal is to see which method more completely removes the lesions and prevents them from coming back within a year, without using ablation therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)
What this could lead to
If one technique proves superior, it could become the standard approach for removing early-stage lesions in Barrett's esophagus, reducing the risk of cancer progression.
What could go wrong
This is a single trial with 331 participants, and results may not apply to all patients. ESD is more complex and carries a higher risk of complications like bleeding or perforation.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Amsterdam University Medical Center
RECRUITINGAmsterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Catharina Ziekenhuis
RECRUITINGEindhoven, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Erasmus Medical Center
RECRUITINGRotterdam, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Antonius Ziekenhuis
RECRUITINGNieuwegein, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Medical Center Groningen
RECRUITINGGroningen, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Medical Center Utrecht
RECRUITINGUtrecht, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••