Battle of the scopes: which technique best wipes out Barrett's lesions?

NCT ID NCT05276791

Recruiting now Disease control Sponsor: St. Antonius Hospital Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This trial compares two endoscopic procedures—endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)—for removing visible precancerous lesions in people with Barrett's esophagus. About 331 adults with Barrett's esophagus and early-stage abnormal tissue will be randomly assigned to one of the two techniques. The goal is to see which method more completely removes the lesions and prevents them from coming back within a year, without using ablation therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD)
What this could lead to: If one technique proves superior, it could become the standard approach for removing early-stage lesions in Barrett's esophagus, reducing the risk of cancer progression.
What could go wrong: This is a single trial with 331 participants, and results may not apply to all patients. ESD is more complex and carries a higher risk of complications like bleeding or perforation.

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Conditions

The condition(s) this trial relates to.

Barrett adenocarcinoma Barrett esophagus esophageal cancer Esophageal Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARRETT ADENOCARCINOMA BARRETTS ESOPHAGUS WITH DYSPLASIA ESOPHAGEAL CANCER

Contacts and locations

Locations

Amsterdam University Medical Center
RECRUITING

Amsterdam, Netherlands
Catharina Ziekenhuis
RECRUITING

Eindhoven, Netherlands
Erasmus Medical Center
RECRUITING

Rotterdam, Netherlands
St. Antonius Ziekenhuis
RECRUITING

Nieuwegein, Netherlands
University Medical Center Groningen
RECRUITING

Groningen, Netherlands
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands

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