Childhood eosinophilic esophagitis

This pilot study looks at whether children with eosinophilic esophagitis (EoE) can safely eat heated forms of cow's milk and hen's egg without their disease coming back. Researchers will gradually introduce less heated versions to see if tolerance can be built. The trial involves…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…