Eosinophilic gastrointestinal disease

This study tests the drug dupilumab in children as young as 6 months who have active eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus and can make eating difficult. The goal is to see if the drug is safe and effective over 24 weeks. About 20 c…

This pilot study looks at whether children with eosinophilic esophagitis (EoE) can safely eat heated forms of cow's milk and hen's egg without their disease coming back. Researchers will gradually introduce less heated versions to see if tolerance can be built. The trial involves…

This study tests if taking a budesonide tablet once daily works as well as taking it twice daily for adults with eosinophilic esophagitis, a condition where immune cells damage the esophagus. About 308 adults with active disease will receive one of the two dosing schedules for 6 …

This study is testing whether a dairy-free diet combined with a special liquid nutrition drink (Kate Farms formula) can help children with eosinophilic esophagitis (EoE) achieve remission. EoE is a condition where the esophagus becomes inflamed, often due to food allergies. The t…

This study tests a new injectable steroid called EP-104GI for adults with eosinophilic esophagitis, a condition where the esophagus becomes inflamed and makes swallowing difficult. The drug is given during an endoscopy and is designed to release medication slowly over time. The t…

This study tests a drug called Zemaira in 15 adults with eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing pain and trouble swallowing. Participants receive Zemaira infusions for 4 weeks to see if it reduces inflammation and improves…

This study is testing the drug dupilumab in 20 children whose eosinophilic gastrointestinal disorders have not responded to other treatments. The goal is to see if dupilumab can heal ulcers and reduce inflammation in the stomach and gut. Children receive injections every one or t…

This study tests whether a simple esophageal string test (EST) can diagnose eosinophilic esophagitis (EoE) in people who have trouble swallowing. Participants swallow a capsule with a nylon string that collects fluid from the esophagus, which is then analyzed. The results will be…

This study tests a new FDA-approved device called MuVI that measures electrical resistance in the esophagus to diagnose GERD and eosinophilic esophagitis. Researchers will enroll 50 adults with chronic esophageal symptoms who are already scheduled for an upper endoscopy. The goal…

This Mayo Clinic study tests if a simple sticker (surface EMG) on the neck can measure how well people with Eosinophilic Esophagitis swallow food. Researchers will compare the sticker's readings to a standard scope exam. The study enrolls 30 adults — both healthy volunteers and E…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This study follows 200 adults and children with eosinophilic esophagitis (EoE) in Italy to learn how the disease progresses over time and how well current treatments work. EoE is an allergic condition that causes swallowing problems and can lead to scarring if not treated. The re…

This study watches how people with eosinophilic esophagitis (EoE) use the medicine Dupixent in everyday care. Researchers will collect information from about 350 patients to learn more about the disease and how treatment affects symptoms and quality of life. No new treatments are…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study looks at a newly identified condition called FIRE (Food Induced Immediate Response of the Esophagus) in children with eosinophilic esophagitis. Researchers want to find out how common FIRE is and describe its symptoms, like chest pain or choking within minutes of eatin…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study observes children with eosinophilic esophagitis (EoE) to understand how their symptoms, endoscopy findings, and inflammatory markers change over time during standard care. Researchers will collect data from up to 1,500 participants during routine clinic and endoscopy v…

This study looks back at 483 patients who had small rectal neuroendocrine tumors (less than 2 cm) removed using one of two endoscopic techniques: endoscopic submucosal dissection (ESD) or endoscopic partial muscle resection (EPMR). The goal is to compare how often each method lea…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study tests a decision support tool for adults with eosinophilic esophagitis (EoE). About 40 participants will use either the tool or general education before a clinic visit. Researchers want to see if the tool is helpful and easy to use, and if it improves treatment knowled…

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This study is creating a registry of 500 patients with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect questionnaires, endoscopy images, biopsy samples, and physical exam findings to learn…

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal care. Researchers will collect information on medical history, symptoms, and quality of life over two years to see how well the treatment works in real-world setti…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This pilot study at Indiana University will test whether a 2-month course of high-dose proton pump inhibitors (PPIs) can improve the flexibility (distensibility) of the esophagus in 10 people with eosinophilic esophagitis (EoE). Researchers will measure flexibility in both the up…

This study is looking at how eosinophils (a type of white blood cell) grow, move, and cause inflammation in people with eosinophilic gastrointestinal disease, other eosinophilic inflammatory conditions, or food allergies. Researchers will also study healthy volunteers and family …

This study is looking at people with eosinophilic gastrointestinal disorders, which cause inflammation in the gut. Researchers want to see if simple questionnaires can tell how well a patient is doing, compared to looking at tissue samples from endoscopies. The goal is to find be…

This study aims to find noninvasive biomarkers—like substances in urine, blood, or saliva—that can accurately detect active eosinophilic esophagitis in children. Currently, diagnosis and monitoring require repeated endoscopies with biopsies under anesthesia. Researchers will coll…