Hope for stomach cancer: new combo trial aims to extend life

NCT ID NCT07270991

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding fruquintinib to the standard drug trifluridine/tipiracil helps people with advanced stomach or gastro-esophageal cancer live longer. About 324 participants who have already tried at least two prior treatments will receive either the combo or trifluridine/tipiracil alone. The goal is to see if the combination improves overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
trifluridine/tipiracil and fruquintinib
What this could lead to
If successful, this combination could offer a new treatment option that extends life for patients with advanced stomach cancer who have run out of standard therapies.
What could go wrong
This is a Phase 3 trial, but the benefit may be modest (months, not years). Side effects from the drug combo could be significant, and the trial may not show a survival advantage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • BORDEAUX-Institut Bergonié

    NOT_YET_RECRUITING

    Bordeaux, France

  • Bayonne- Clinique Belharra

    NOT_YET_RECRUITING

    Bayonne, France

  • C.H.U. de Brest

    NOT_YET_RECRUITING

    Brest, 29200, France

  • CAC - Paul Strauss

    NOT_YET_RECRUITING

    Strasbourg, France

  • CAC Antoine Lacassagne

    NOT_YET_RECRUITING

    Nice, France

  • CAC Jean Godinot

    NOT_YET_RECRUITING

    Reims, France

  • CAC Paoli Calmettes

    NOT_YET_RECRUITING

    Marseille, France

  • CHRU Nancy Brabois

    NOT_YET_RECRUITING

    Vandœuvre-lès-Nancy, France

  • CHRU de Tours - Hopital Trousseau

    NOT_YET_RECRUITING

    Tours, 37044, France

  • CHU - Charles Nicolle

    NOT_YET_RECRUITING

    Rouen, France

  • CHU Côte de Nacre

    NOT_YET_RECRUITING

    Caen, France

  • CHU Dupuytren

    NOT_YET_RECRUITING

    Limoges, France

  • CHU de Saint Etienne - Hôpital Nord

    NOT_YET_RECRUITING

    Saint-Priest-en-Jarez, 42270, France

  • Cac - François Baclesse

    NOT_YET_RECRUITING

    Caen, France

  • Center Hospitalier de Sens

    NOT_YET_RECRUITING

    Sens, 89108, France

  • Centre Eugène Marquis

    NOT_YET_RECRUITING

    Rennes, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Aurillac, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Bayeux, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Cholet, France

  • Centre Hospitalier

    NOT_YET_RECRUITING

    Pau, 64046, France

  • Centre Hospitalier Côte Basque

    NOT_YET_RECRUITING

    Bayonne, France

  • Centre Hospitalier Emile Roux

    NOT_YET_RECRUITING

    Le Puy-en-Velay, France

  • Centre Hospitalier Lyon Sud

    NOT_YET_RECRUITING

    Pierre-Bénite, 69495, France

  • Centre Hospitalier Prive Saint Gregoire

    NOT_YET_RECRUITING

    Saint-Grégoire, France

  • Centre Hospitalier Saint Jean

    NOT_YET_RECRUITING

    Perpignan, France

  • Centre Leonard de Vinci

    NOT_YET_RECRUITING

    Dechy, France

  • Ch - Jean Rougier

    NOT_YET_RECRUITING

    Cahors, France

  • Ch Memorial France Etats Unis

    NOT_YET_RECRUITING

    Saint-Lô, France

  • Ch Nord Ouest

    NOT_YET_RECRUITING

    Villefranche-sur-Saône, France

  • Chu - Aphp - Hôpital Saint Louis

    NOT_YET_RECRUITING

    Paris, 75475, France

  • Chu - Centre Hospitalier Universitaire Robert Debre

    NOT_YET_RECRUITING

    Reims, 51092, France

  • Chu - Centre Hospitalier Universitaire de Poitiers - La Miletrie

    RECRUITING

    Poitiers, 86021, France

  • Chu - Hôpital Européen Georges Pompidou

    NOT_YET_RECRUITING

    Paris, France

  • Chu - Hôpital La Timone

    NOT_YET_RECRUITING

    Marseille, 13385, France

  • Clinique Mathilde

    NOT_YET_RECRUITING

    Rouen, France

  • Clinique Mutualiste de L'Estuaire

    NOT_YET_RECRUITING

    Saint-Nazaire, France

  • Clinique Sainte Anne

    NOT_YET_RECRUITING

    Strasbourg, France

  • Clinique Tivoli

    NOT_YET_RECRUITING

    Bordeaux, France

  • Clinique de Flandre

    NOT_YET_RECRUITING

    Coudekerque-Branche, France

  • Clinique de La Croix du Sud

    NOT_YET_RECRUITING

    Quint-Fonsegrives, France

  • Confluent Sas

    NOT_YET_RECRUITING

    Nantes, France

  • Gh Nord Essone

    NOT_YET_RECRUITING

    Orsay, France

  • Groupe Hospitalier Rance Emeraude

    NOT_YET_RECRUITING

    St-Malo, France

  • Groupement Hospitalier Bretagne Sud

    NOT_YET_RECRUITING

    Lorient, France

  • Haematologisch Onkologische Praxis Eppendorf

    NOT_YET_RECRUITING

    Hamburg, Germany

    Contact Email: •••••@•••••

  • Hia Begin

    NOT_YET_RECRUITING

    Saint-Mandé, France

  • Hia Sainte Anne

    NOT_YET_RECRUITING

    Toulon, France

  • Hôpital Cochin (APHP)

    NOT_YET_RECRUITING

    Paris, France

  • Hôpital FOCH

    NOT_YET_RECRUITING

    Suresnes, France

  • Hôpital Franco-Britannique

    NOT_YET_RECRUITING

    Levallois-Perret, France

  • Hôpital Prive Jean Mermoz

    NOT_YET_RECRUITING

    Lyon, 69008, France

  • ICONE

    NOT_YET_RECRUITING

    Bezannes, France

  • Institut Sainte Catherine

    NOT_YET_RECRUITING

    Avignon, 84000, France

  • Institut de cancérologie de Bourgogne GRReCC

    NOT_YET_RECRUITING

    Dijon, France

  • KEM/Evang. Kliniken Essen Mitte gGmbH

    NOT_YET_RECRUITING

    Essen, Germany

  • Klinikum Chemnitz gGmbH

    NOT_YET_RECRUITING

    Chemnitz, Germany

  • Klinikum Rechts Der Isar Der Technischen Universitat Munchen

    NOT_YET_RECRUITING

    München, Germany

  • Krankenhaus Nordwest GmbH

    NOT_YET_RECRUITING

    Frankfurt, Germany

  • Polyclinique

    NOT_YET_RECRUITING

    Rillieux-la-Pape, France

  • Privé - Groupe Hospitalier Diaconesses Croix Saint Simon

    NOT_YET_RECRUITING

    Paris, 75020, France

  • Rostock University Medical Center

    NOT_YET_RECRUITING

    Rostock, Germany

  • Saint Côme

    NOT_YET_RECRUITING

    Compiègne, France

  • Uniklinikum Leipzig

    NOT_YET_RECRUITING

    Leipzig, Germany

  • Universitätsklinikum Jena

    NOT_YET_RECRUITING

    Jena, Germany

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