Upper digestive tract disorder

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial co…

This study compared two ways to fix a failed mitral heart valve replacement: a less invasive procedure called valve-in-valve (using a catheter to place a new valve inside the old one) versus repeat open-heart surgery. The trial included 150 adults with severe valve problems. Rese…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested a new drug called BLI5100 in 1250 adults with erosive esophagitis, a condition where stomach acid damages the esophagus. Participants took either BLI5100 or a standard PPI (proton pump inhibitor) daily for up to 8 weeks to see if it healed the damage, then for 2…

This study tested two experimental drugs (AK104 and AK117) together, sometimes with chemotherapy, in 128 people with advanced solid tumors. The goal was to see if the combination is safe and can shrink tumors. It focused on patients with stomach, esophageal, or other advanced can…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study tested a new drug called MK-1200 in 13 people with advanced solid tumors, including stomach, esophageal, bile duct, and pancreatic cancers. The goal was to find safe doses and see if the drug could shrink tumors. The study is complete, but results are not yet available…

This phase III trial tested whether adding trastuzumab (Herceptin) to standard chemotherapy and radiation helps people with HER2-positive esophageal cancer. 203 patients were randomly assigned to get chemo and radiation with or without trastuzumab. The study measured how long pat…

This study tested whether adding an experimental drug called LBL-007 to standard immunotherapy and chemotherapy helps shrink tumors better in people with advanced esophageal cancer that cannot be surgically removed. About 118 participants received either the three-drug combo or t…

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the…

This phase 2 trial tested a biologic drug called barzolvolimab in 86 adults with active eosinophilic esophagitis, a condition that causes trouble swallowing due to inflammation in the esophagus. Participants received either the drug or a placebo as a shot under the skin. The stud…

This study looked at whether a specific keyhole surgery (Toupet fundoplication) can help people with a hiatal hernia that causes heartburn but doesn't show up on X-rays. 100 adults with this condition had the surgery and were followed to see if their symptoms came back or if they…

This phase 2 trial tested a two-step treatment for advanced esophageal cancer that has a specific genetic marker (MGMT deficiency) and has stopped responding to standard chemotherapy. First, patients took a daily oral chemotherapy drug (temozolomide) for three months. Then, they …

This study tested a new surgical technique for esophageal cancer that avoids a large chest incision. 35 patients with early-stage cancer received this less invasive procedure. The goal was to see if it could lower complication rates while still effectively removing the cancer. Re…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This study tested whether a personalized diet, based on a blood test that identifies food allergies, can help people with eosinophilic esophagitis (EoE). 56 participants were randomly assigned to either a personalized elimination diet or a sham diet. The goal was to see if the pe…

This study tested whether adding a crural repair and gastropexy to standard sleeve gastrectomy reduces acid reflux in people with severe obesity. Fifty patients were randomly assigned to either the standard surgery or the enhanced version. After one year, the group with the extra…

This study compared two surgical methods for removing esophageal cancer: open surgery versus a less invasive approach using a laparoscope. The goal was to see if the laparoscopic method reduces serious complications within 30 days after surgery. The trial involved 207 patients wi…

This phase 3 trial tested whether adding the immunotherapy drug tislelizumab to standard chemoradiotherapy helps people with localized esophageal squamous cell carcinoma. 370 participants received either tislelizumab or a placebo alongside chemotherapy and radiation. The study me…

This study tested whether tracking daily steps with a simple pedometer could help identify cancer patients at high risk of being hospitalized during chemoradiotherapy. 40 adults with head and neck, lung, esophageal, or stomach cancer wore a pedometer and received extra support li…

This phase 3 trial tested whether adding two immunotherapy drugs, atezolizumab and tiragolumab, to standard chemotherapy could help people with advanced esophageal cancer live longer. About 461 participants received either the immunotherapy combo plus chemo or a placebo plus chem…

This early-phase trial tested a combination of two targeted drugs (regorafenib and nivolumab) plus standard chemotherapy in 30 adults with advanced or recurrent stomach, gastroesophageal junction, or esophageal adenocarcinoma that could not be surgically removed. The goal was to …

This phase II trial tested a combination of two chemotherapy drugs, cisplatin and irinotecan, given weekly along with radiation therapy for patients with locally advanced esophageal cancer. The study enrolled 43 participants and aimed to see how many had no detectable tumor after…

This study looks at the long-term safety of a drug called CC-93538 (cendakimab) for people with eosinophilic esophagitis, a condition that causes inflammation in the esophagus. It enrolled 367 adults and teens who had already taken part in earlier studies of the same drug. The ma…

This phase 2 trial tests the drug utidelone in 126 people with advanced solid tumors (excluding breast, lung, and colorectal cancers) that have not responded to standard treatments. The study aims to see if the drug can shrink tumors and how safe it is. Participants receive utide…

This study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …

This phase 2 trial tested two experimental drugs, lomvastomig and tobemstomig, against the standard immunotherapy nivolumab in 190 people with advanced esophageal cancer that had worsened after chemotherapy. The drugs are bispecific antibodies designed to block two immune checkpo…

This study compared two procedures for treating achalasia, a condition where the esophagus doesn't relax properly. One is a balloon dilation (pneumodilation) and the other is a surgery called POEM done through a scope. 132 adults with achalasia were randomly assigned to one treat…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This early study tested a combination of the immunotherapy drug pembrolizumab (Keytruda) and internal radiation (brachytherapy) in 16 people with metastatic esophageal cancer. The goal was to see if the radiation could help the immune system attack the cancer more effectively. Th…

This study compared two chemotherapy regimens (FOLFOX and CarboP-pacliT) given with radiation before surgery for esophageal or junction cancer. 106 patients were enrolled to see which treatment leads to better tumor removal and fewer serious complications. The goal is to help doc…

This study looked at whether using different oxygen concentrations during and after esophageal cancer surgery could lower the risk of lung collapse (atelectasis). 65 patients were randomly assigned to receive either 30% or 60% oxygen during two-lung ventilation. The main goal was…

This study tested a new drug called BI 3706674 in 47 adults with advanced stomach or esophageal cancer that had not responded to prior treatment. The drug is a tablet that blocks growth signals in cancer cells. The main goals were to find a safe dose and see if the drug could shr…

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This study tested whether adding the immunotherapy drug pembrolizumab after standard chemoradiotherapy and surgery could prevent cancer recurrence in 26 patients with high-risk esophageal squamous cell carcinoma. Participants received cisplatin-based chemoradiotherapy followed by…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This study looked at how well endoscopic stenting and suturing work to close holes or tears in the esophagus. Researchers reviewed 150 patients treated at a large referral center. The goal was to see which technique leads to better healing.

This study tested a temporary blood-flow restriction procedure (ischemic conditioning) done about two weeks before esophageal cancer surgery. It included 22 patients with artery calcifications who were at higher risk for leaks where the new connection is made. The goal was to see…

This phase 3 trial tested whether adding immunotherapy drugs (nivolumab and ipilimumab) to standard chemotherapy helps people with advanced esophageal cancer live longer or keep their cancer from growing. About 970 participants with inoperable or metastatic esophageal squamous ce…

This completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…

This study tested two drugs, olaparib and ramucirumab, in 51 people with advanced stomach or gastroesophageal junction cancer that had spread or could not be removed. The goal was to find the best dose and see how well the combination worked. The trial is complete, and results ma…

This study tested whether a special stent (a small mesh tube) usually used for bile ducts could help children with a narrowed esophagus (food pipe). Forty children were randomly assigned to get either the stent or standard surgery. The main goal was to see how often the narrowing…

This study looked at 120 people with esophageal cancer who had a type of surgery called McKeown esophagectomy. Half had the right gastric artery preserved, and half had it tied off. The goal was to see if preserving the artery lowers the chance of leaks or narrowing where the new…

This study tested a special stapler during a combined weight-loss and anti-reflux surgery called Nissen Sleeve. It involved 167 people with obesity and GERD. The goal was to see if the surgery reduces acid reflux and if the stapler works safely.

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This early-phase trial tested an experimental drug called ezabenlimab, alone or combined with another drug (BI 754111), in 146 Asian patients with advanced solid tumors. The main goals were to check safety, find the right dose, and see if the combination shrinks tumors in cancers…

This early-stage trial tested the safety of a new drug called SGN-B6A in 6 Chinese patients with advanced solid tumors (lung, head and neck, esophageal, stomach cancers). The main goal was to identify side effects and see how the body processes the drug. It is a first step to see…

This study tested several immunotherapy-based drug combinations in 214 people with advanced stomach, gastroesophageal junction, or esophageal cancer that could not be removed by surgery or had spread. Participants received either standard chemotherapy or chemotherapy plus the imm…

This study tested several combinations of the immunotherapy drug pembrolizumab (Keytruda) with other drugs in 90 people with advanced esophageal cancer that had already progressed after one prior treatment. The goal was to see if these combinations are safe and can shrink tumors …

This phase 2 trial tested whether adding the immunotherapy drug tislelizumab to chemotherapy and/or radiation before surgery could help completely eliminate esophageal cancer in 70 patients. The goal was to see if the tumor and all cancer cells in lymph nodes were gone at the tim…

This early-phase trial tested a new treatment called CTX131 for adults with advanced solid tumors that have not responded to standard therapies. The treatment uses donor immune cells that are gene-edited to target a protein called CD70 found on cancer cells. The study enrolled 19…

This study looked at 200 people with advanced esophageal cancer to compare two treatments before surgery: immunotherapy combined with chemotherapy, versus chemotherapy plus radiation. Both treatments led to similar long-term survival rates. The immunotherapy combo may offer extra…

This Phase 2 trial tested whether adding the immunotherapy drug durvalumab to standard chemoradiation (FOLFOX and radiation) helps patients with unresectable esophageal cancer. 112 patients were randomly assigned to receive either chemoradiation alone or chemoradiation plus durva…

This study tested whether the immunotherapy drug nivolumab can help prevent esophageal cancer from coming back after surgery. About 794 people who had surgery for stage II or III cancer of the esophagus or gastroesophageal junction received either nivolumab or a placebo. The main…

This early-phase trial tested a combination of three drugs—afuresertib, sintilimab, and chemotherapy—in 22 adults with solid tumors (including lung, cervical, and stomach cancers) that had stopped responding to prior immunotherapy. The goal was to find a safe dose and see if the …

This study tested whether adding a gut-brain neuromodulator (Flupentixol-Melitracen) to standard acid-reducing therapy (Lansoprazole) helps people with gastroesophageal reflux disease (GERD) who still have symptoms on acid suppressants alone. The trial enrolled 164 adults with GE…

This study tested whether the drug dupilumab can help children and young adults (ages 6 to 25) with eosinophilic esophagitis (EoE) safely reintroduce foods that normally trigger their symptoms. EoE is a condition where certain foods cause inflammation in the esophagus, and curren…

This phase 2 trial tested a combination of two chemotherapy drugs (capecitabine and oxaliplatin) plus two targeted antibodies (bevacizumab and trastuzumab) in 37 people with HER2-positive stomach or esophageal cancer that had spread. The goal was to see how safe and effective the…

This study tested dupilumab (Dupixent) in 102 children with active eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing pain and swallowing problems. The drug aims to reduce inflammation and improve tissue health. Results will show if d…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study compared two endoscopic treatments for Barrett's esophagus, a condition that can lead to esophageal cancer. The goal was to see which procedure—radiofrequency ablation or hybrid argon plasma coagulation—causes less pain and is safer from the patient's viewpoint. Sixty-…

This study compared two treatments for early-stage esophageal cancer in people with Barrett's esophagus: a new, less invasive procedure using radiofrequency ablation (a balloon that burns away abnormal cells) versus standard surgery to remove part of the esophagus. The goal was t…

This study tested a new procedure called POEM for people with achalasia, a condition where the esophagus doesn't relax properly, making swallowing hard. In POEM, doctors cut the tight muscle through a small tunnel inside the esophagus, without any cuts on the outside. The goal wa…

This study tested a new device called the Tiara valve, which is implanted through a small tube in the chest to replace the leaky mitral valve without open-heart surgery. It enrolled 157 people with severe mitral regurgitation who were considered too high-risk for traditional surg…

This early study tested a device called the Edwards PASCAL system, which is threaded through a blood vessel to repair the tricuspid valve in the heart. The valve can leak, causing symptoms like shortness of breath and swelling. The study included 65 people with severe leakage who…

This study tested a new drug called SAR444245 combined with other cancer treatments in 138 adults with advanced gastrointestinal cancers, including esophageal, stomach, liver, and colorectal cancer. The goal was to see if the combination could shrink tumors. The study is complete…

This study checked the safety of taking BLI5100 daily for up to 12 months in 400 adults with gastroesophageal reflux disease (GERD). Participants had either non-erosive reflux disease or healed erosive esophagitis. The main goal was to track any side effects. This is a disease co…

This study tested a procedure called radiofrequency ablation (using heat to remove abnormal cells) in 125 people with Barrett's esophagus and low-grade dysplasia. Participants were randomly assigned to receive the ablation or regular endoscopic monitoring. The goal was to see if …

This study tested whether adjusting the dose of a common acid reflux medicine (lansoprazole) based on a child's genes could improve asthma control. 41 children aged 6-17 with uncontrolled asthma and mild reflux participated. Researchers measured changes in asthma symptoms and ref…

This pilot study tested high dose rate brachytherapy, a type of internal radiation, in 43 patients with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could deliver the planned dose accurately. Participants received b…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study tested a new, faster way to diagnose GERD (heartburn disease) using a special probe during a routine endoscopy. The test takes only one minute and may be more comfortable than current methods. Fifteen adults with known reflux participated, and their results were compar…

This study tested two radioactive imaging agents, NDX-3315 and NDX-3324, to see if they can safely and accurately detect eosinophilic esophagitis (EoE), a condition where immune cells build up in the esophagus. It involved 34 people—some healthy and some with EoE. The goal was to…

This study tested a new, office-based test called EsoCheck/EsoGuard to detect Barrett's esophagus in 132 people who do not have chronic heartburn but have other risk factors like being over 50, white, male, or having central obesity. Participants swallowed a capsule on a string t…

This study tested whether a wired magnetic capsule endoscopy system produces fewer airborne droplets than traditional endoscopy when checking for esophageal varices in people with biliary atresia. Fifty participants underwent either the capsule or standard procedure. The main goa…

This study tested a new way to spot cancer in people with Barrett's esophagus, a condition that can lead to esophageal cancer. Doctors sprayed a weak vinegar solution on the esophagus and timed how long the tissue stayed white. They found that cancerous or pre-cancerous areas los…

This study tested whether a special camera technique (virtual chromoendoscopy) can find pre-cancerous or cancerous spots in Barrett's esophagus better than the standard method of taking random biopsies. 110 adults with Barrett's esophagus took part. The goal was to see if the new…

This study tested whether a computer model could predict if esophageal cancer completely disappears after chemo-immunotherapy. Researchers reviewed medical records and CT scans from 363 patients who received standard treatment before surgery. The AI combined clinical data, radiom…

This study looked at whether starting feeding through a tube soon after esophageal cancer surgery can lower infection rates and help the gut work again. 70 adults who had their esophagus removed took part. The goal was to see if early feeding reduces complications like leaks and …

This study tested whether PepZinGI, a zinc-L-carnosine supplement, can reduce heartburn triggered by food. Fifty adults with frequent heartburn completed two one-week treatment periods (PepZinGI and placebo) remotely, using wearable devices and surveys to track symptoms and sleep…

This study compared two different surgical knives used during a procedure called POEM, which treats swallowing disorders by cutting throat muscles. 104 adults were randomly assigned to receive either a standard monopolar knife or a newer bipolar knife (Speedboat-RS2). The goal wa…

This study looked at whether a swaddle blanket with a gentle abdominal band can reduce acid reflux, breathing pauses, heart rate drops, and low oxygen levels in premature infants. About 50 babies in the NICU were observed to see if the blanket helped. The goal was to find a simpl…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study tested whether a low-FODMAP diet could help people with gastro-esophageal reflux disease (GERD) whose symptoms persist despite taking standard acid-reducing drugs (PPIs). Thirty-one adults with confirmed reflux were randomly assigned to either a low-FODMAP diet or a st…

This study tested if using water instead of carbon dioxide gas during a throat muscle procedure (POEM) could lower pain afterward. 34 adults with swallowing problems took part. The goal was to see which method led to less pain, fewer pain meds, and fewer hospital readmissions.

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether six weeks of supervised Pilates exercises could reduce symptoms of gastroesophageal reflux disease (GERD) in 33 adults. Participants did 18 sessions of posture-focused Pilates or continued their usual daily activities. Researchers measured changes in ref…

This study tested whether Polaprezinc (Zinc-L carnosine) can reduce reflux symptoms in infants aged 1-12 months. Sixty babies were given either the supplement or a thickened formula twice daily for 8 weeks. Researchers measured changes in a reflux symptom questionnaire to see if …

This study tested a new syrup, called Fibroin Syrup, to see if it is safe and can help reduce symptoms of gastroesophageal reflux disease (GERD), like heartburn and regurgitation. The study included 47 adults with non-erosive reflux disease (NERD) who had symptoms for at least 8 …

This study compared two medications, esomeprazole and vonoprazan, for treating gastroesophageal reflux disease (GERD). Researchers enrolled 824 adults aged 18 to 65 with GERD and measured how many achieved sufficient symptom relief. The goal was to find which drug works better fo…

This study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…

This study tested whether alginate (Gaviscon) or sucralfate (Ulsanic) provides better symptom relief for people with GERD who are already taking acid-reducing medication (PPIs). 140 adults with frequent severe heartburn took one of the two syrups before meals. Researchers measure…

This pilot study tested whether spray cryotherapy (freezing the tumor from inside the esophagus) can quickly improve swallowing in 15 patients with advanced esophageal cancer who were about to start chemotherapy and radiation. The goal was to ease difficulty swallowing sooner tha…

This study tested whether a mild electrical stimulation at specific acupoints (TEAS) helps people with cirrhosis tolerate an urgent endoscopy for suspected variceal bleeding. 180 patients were split into three groups: active TEAS, sham TEAS (electrodes but no current), or standar…

This study tested whether an education and support program can help family caregivers of cancer patients feel more confident and less anxious. About 484 caregivers and patients took part. Researchers compared different types of support to see which worked best.

This phase II trial tested a concentrated plant dietary supplement (made from foods like taro, rice, and carrots) in 30 people with gastrointestinal cancers who had diarrhea from chemotherapy. Participants received the supplement alongside standard anti-diarrheal treatment. The g…

This study tested whether a mobile app helps cancer patients undergoing chemotherapy or radiation therapy report their symptoms more effectively. Over 200 participants used the app to track side effects for 8 weeks. The goal was to see if the app improves how patients recognize a…

This early-stage trial tested a new drug called DW4421 in 24 healthy adults to see how food changes the way the body absorbs it. The goal is to learn whether the drug should be taken with or without food for future studies. This is a safety and dosing study, not a test of whether…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested whether fexuprazan, a new drug, can relieve heartburn and acid reflux as well as the commonly used esomeprazole. 145 adults with GERD took either fexuprazan or esomeprazole once daily for 4 weeks, with an option to continue for another 4 weeks if symptoms didn't…

This study looked at whether having a palliative care team work alongside surgeons improves quality of life for patients with gastrointestinal cancers like pancreatic or liver cancer. About 379 patients and their family members took part. The main goal was to see if this team app…

This pilot study tested whether people with eosinophilic esophagitis (EoE) triggered by milk can safely eat baked milk. Seven participants ate a baked milk muffin daily for six weeks. Researchers measured if this led to fewer eosinophils (a type of white blood cell) in the esopha…

This study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can ease symptoms of nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either the toxin or a placebo in a double-blind setup. The m…

This study tested a digital platform designed to help patients recover physically and mentally after major surgery for esophageal or laryngeal cancer. The platform offered short daily exercise sessions. The study included 30 patients and focused on whether they would use the tool…

This study tested whether a high-flow nasal cannula (HFNC) can reduce the risk of low oxygen levels during sedated gastrointestinal endoscopy in 80 adults with high-risk obstructive sleep apnea. Participants had a STOP-Bang score of 5 or higher and were undergoing gastroscopy, co…

This study tested whether gut-directed hypnotherapy (GDH) delivered via telehealth could help manage gastrointestinal symptoms in adults with disorders of gut-brain interaction. Eleven participants completed sessions of general relaxation hypnosis and GDH, plus a 3-month follow-u…

This study looked at whether taking zinc supplements can improve quality of life for people with advanced gastrointestinal cancers (like stomach, liver, or pancreatic cancer) who are receiving chemotherapy. Seventeen patients participated, and researchers measured their quality o…

This study looked at 38 people with achalasia cardia, a condition where the esophagus muscle doesn't relax, making swallowing difficult. Half had laparoscopic (minimally invasive) surgery and half had open surgery. Researchers measured symptoms and quality of life before and afte…

This study tested whether a liquid dietary supplement called Anvitra Gastric Suspension can reduce heartburn, regurgitation, and indigestion in people with GERD. Twenty-seven adults took the supplement three times daily for 14 days. Researchers measured symptom changes using a st…

This completed study looked at whether FEXUCLUE (fexuprazan) tablets can improve heartburn and acid reflux symptoms in people with erosive gastroesophageal reflux disease (GERD). Over 2,800 adults took the medication for 4 to 8 weeks and reported their symptom changes. The goal w…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This early-phase trial tested the safety and tolerability of a drug called X842 in 39 healthy adults. Participants received either single or multiple doses of X842 to see how the body handles it and what side effects may occur. The study is complete and does not aim to treat any …

This study looked at 100 patients who had sleeve gastrectomy for severe obesity. Researchers checked how many developed Barrett's esophagus, a condition that can lead to esophageal cancer, five or more years after surgery. They also examined whether routine endoscopy (a camera te…

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This study reviewed medical records of 500 adults treated for benign or malignant pancreatic and stomach diseases from 2005 onward. Researchers looked at overall survival after various treatments. The goal was to understand real-world outcomes, not to test a new drug or procedure…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study reviewed the medical records of 569 adults who had surgery for lung or esophageal cancer. Researchers wanted to see if taking statins (cholesterol-lowering drugs) around the time of surgery was linked to fewer complications and better long-term outcomes. The goal is to…

This study looked at 480 cirrhosis patients who had variceal bleeding and were getting an endoscopy to prevent future bleeding. Half got antibiotics before the procedure, half did not. The goal was to see if antibiotics reduce infections after the procedure. The study is retrospe…

This early-stage study tested two different forms of the experimental drug AQ280 in 9 healthy adults. The goal was to see how well the body absorbs the drug when given as a capsule versus a tablet that dissolves in water. The results will help researchers decide which form to use…

This study looked at 24 people with lung or esophageal cancer who received radiation or chemo-radiation near the heart. Participants wore a small heart monitor to catch any heart changes that might otherwise go unnoticed. The goal was to see how often heart problems occur after s…

This study looked at 7 adults with achalasia, a swallowing disorder, to find out why some lose weight and others don't. Researchers monitored body weight and compared differences between the two groups. The goal was to gather information that could lead to better understanding an…

This study looked at 412 people with cirrhosis who had bleeding from veins in the esophagus or stomach. Half got an endoscopy within 6 hours, the other half between 6 and 24 hours. The goal was to see if faster treatment lowered the chance of rebleeding within 42 days. The result…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study analyzed data from nearly 3,000 patients who had surgery for esophageal cancer between 2000 and 2010. Researchers looked at factors like patient health, treatment approach, and surgical technique to see what influences cancer recurrence and survival. The goal is to bet…

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study set up a national registry in France to track babies born with esophageal atresia, a birth defect where the esophagus is not fully formed. Researchers collected data on about 1,460 newborns to understand how common the condition is, what other health issues may occur, …

This study tracked 295 adults who had high-risk surgery for stomach, esophagus, pancreas, or liver cancer. Researchers measured quality of life before surgery and again at 6 and 12 months after. They also asked patients and their family members if they regretted the decision to h…

This study looked back at 387 patients with esophageal cancer to compare two chemotherapy drugs, nab-paclitaxel and paclitaxel, given before surgery. The goal was to see which drug leads to better outcomes like complete cancer removal. The study is completed, but results are not …

This study looked at tissue samples from 6 children born with esophageal atresia, a condition where the esophagus doesn't form properly. Researchers compared biopsies taken during surgery with those stored for up to a year to see if storage time changes the molecular information.…

This study looked at 13 people undergoing a standard esophagus pressure test to see which breathing positions or maneuvers create the highest pressure at the junction between the esophagus and stomach. The goal is to learn how to better contract the diaphragm, which may help with…

This completed study followed over 2,100 people who had surgery (esophagectomy) for esophageal cancer. Researchers tracked how long patients survived after their operation. The goal was to gather real-world data on outcomes, not to test a new treatment.

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study tested a new imaging method to see a protein called PD-L1 in esophageal tumors. PD-L1 levels may help predict if immunotherapy will work, but current biopsy tests are often inaccurate. Researchers gave 21 patients a fluorescent tracer that binds to PD-L1, then used a s…

This study looked at whether routinely measuring leftover stomach volume in patients on breathing machines and feeding tubes helps prevent pneumonia. Researchers compared patients who had these checks every six hours to those who did not. The goal was to see if skipping the check…

This early study looked at how two approved constipation drugs, plecanatide and linaclotide, affect a chemical called cGMP in the small intestine. Researchers compared tissue samples from 43 adults with Barrett esophagus or GERD who took either drug or no drug. The goal was to me…

This study analyzed data from 414 esophageal cancer patients who received chemoimmunotherapy before surgery. Researchers developed a new 'bio-anatomical' staging system that combines tumor characteristics and immune response to better predict survival and guide post-surgery treat…

People with achalasia, a swallowing disorder, have a much higher risk of developing esophageal cancer. This study tested whether spraying a special dye (Lugol) during an endoscopy could help doctors find early signs of cancer (dysplasia) in 39 patients who had achalasia for over …

This study tested a new way to measure blood pressure in stomach veins of 25 people with liver cirrhosis and enlarged veins (varices). Doctors used an endoscope with ultrasound to see if this method could better predict bleeding risk than standard tests. The goal was to see if th…

This study looked at how many people in Xiamen have gastroesophageal reflux disease (GERD) and what factors might increase their risk. Researchers surveyed 1625 adults who had typical reflux symptoms like heartburn. The goal was to better understand the disease's impact and help …

This completed study looked at 100,000 patient records to find out if people with eosinophilic esophagitis (EoE) are more likely to develop esophageal cancer. The researchers wanted to see if any increased risk is due to EoE itself or to other conditions like acid reflux or Barre…

This study looked at specific immune cells in the esophagus of children with eosinophilic esophagitis (EoE) compared to healthy children. Researchers counted these cells and also studied the microbiome. The goal was to better understand the disease, not to test a treatment. 35 ch…

This study looked at 195 adults with achalasia, a rare condition that makes it hard to swallow. Researchers checked if certain antibodies in the blood are linked to how severe the disease is and how well patients respond to a treatment called POEM. The goal was to see if these an…

This early-stage study looked at how a new GERD drug, linaprazan glurate, changes the way the body processes the antibiotic amoxicillin. Twelve healthy adults took amoxicillin alone and then again after a week of the GERD drug. The goal was to measure drug levels in the blood, no…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study looked at whether using MRI scans can reduce differences in how doctors outline esophageal cancer tumors for radiation therapy. Twenty-three patients with advanced esophageal cancer had MRI scans in addition to standard CT and PET/CT scans. Five radiation oncologists i…

This study tested whether a program to improve physical fitness, nutrition, and sleep before surgery is possible for older adults with esophageal cancer. Fifteen patients aged 65 and older who had completed chemotherapy or radiotherapy took part. The goal was to see if patients w…

This study tested whether an AI-assisted software (iCurveE) helps doctors outline organs at risk on CT scans for radiation therapy more accurately and quickly. 500 adults with lung, breast, or esophageal cancer participated. Researchers compared manual outlining, AI-only, and AI-…

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…

This completed study analyzed tumor and blood samples from 160 people with esophageal or rectal cancer. Researchers looked for genetic markers in the EGFR signaling pathway that might predict how well a patient responds to chemoradiotherapy given before surgery. The goal is to be…

This study compared two types of minimally invasive surgery for esophageal cancer: the Ivor-Lewis and McKeown approaches. Researchers looked at complications, recovery, and long-term results in 272 patients. The goal was to see which method might be safer and more effective for t…

This study looked at whether measuring liver pressure during an endoscopy is more accurate when patients lie on their left side versus flat on their back. Researchers tested 30 hospitalized patients with liver cirrhosis. The goal was to see if the two positions give consistent re…

This study analyzed medical records from 1197 patients in China with advanced esophageal cancer who received immunotherapy (anti-PD-1) plus chemotherapy as their first treatment. The goal was to see how long patients lived and how long the cancer stayed under control in everyday …

This completed study examined how to best manage early-stage upper gastrointestinal cancer in patients who also have liver cirrhosis and enlarged veins in the esophagus (varices). Researchers compared outcomes of a keyhole-like endoscopic surgery (ESD) between 206 patients with a…

This study looked at why many cancer patients lose muscle and weight, a condition called cachexia. Researchers collected samples of muscle, fat, blood, and urine from 282 people during cancer surgery and compared them with samples from non-cancer patients. They also measured phys…

This study looked at whether a bedside lung ultrasound can predict lung complications within an hour after esophageal cancer surgery. Researchers followed 274 patients and compared ultrasound findings to standard methods. The goal is to find a faster, safer way to detect problems…

This study tested two types of glottis mask airways (a tube placed in the throat to help patients breathe during anesthesia) to see which one reduces the risk of stomach acid backing up into the throat. The tulip-shaped tip is designed to fit the larynx better than the classical …

This study looked at 258 adults with untreated oeso-gastric cancer to understand how factors like income, education, and personal beliefs affect the time between first noticing symptoms and seeing a doctor. Researchers measured the median delay from symptom onset to first consult…

This study looked at whether two easy-to-use frailty checklists (FRAIL and FiND) can predict severe side effects from chemotherapy in adults aged 65 and older with gastrointestinal cancers. Researchers followed 84 patients who had already had surgery and were receiving standard c…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study compared a generic vonoprazan 20 mg tablet to the brand-name Voquezna in 28 healthy adults. Participants took a single dose of each under fasting conditions to see if the generic releases the same amount of drug into the bloodstream. The goal was to check bioequivalenc…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study tested two types of pictorial warning labels on alcohol to see which better communicates cancer risks. Over 1,000 adults who drink regularly viewed labels with either personal stories (narrative) or images of diseased organs (non-narrative). Researchers measured attent…

This study looked at 100 people with esophageal cancer to see if a very narrow esophagus (stricture) is linked to more advanced cancer. Doctors used an endoscopic ultrasound to stage the cancer. The goal was to learn if a tight stricture means the cancer is harder to treat.

This study looked at whether a non-endoscopic device (EsoCheck) and a biomarker test (EsoGuard) can help doctors decide when to refer patients for a standard upper endoscopy to screen for Barrett's esophagus. 97 doctors reviewed patient cases and made referral decisions, first wi…

This study looked at whether detergents found in common products like toothpaste can make the lining of the esophagus leaky and cause allergic inflammation, which is a key feature of eosinophilic esophagitis. Researchers tested 12 healthy volunteers by measuring changes in the es…

This completed study surveyed over 700 primary care doctors, gastroenterologists, and patients across seven U.S. health systems. The goal was to find out what knowledge gaps, attitudes, and practical barriers prevent people from getting screened for Barrett's esophagus, a conditi…

This study looked at 577 patients who had surgery for esophageal cancer. Researchers compared two ways of giving nutrition after surgery: feeding through a tube placed directly into the small intestine (jejunostomy) versus a tube through the nose into the stomach (nasoenteric). T…

This study reviewed the medical records of over 3,100 people who had surgery to remove esophageal cancer at a major hospital in South Korea. The goal was to learn about common complications after surgery and how long patients lived afterward. The findings can help doctors improve…

This study looked at 605 patients with esophageal cancer who had minimally invasive surgery to remove their esophagus. Researchers compared those with and without type 2 diabetes to see if diabetes affected short-term complications and long-term survival. The goal is to understan…

This study looked at whether having cancer patients report their own symptoms during radiation treatment helps doctors notice and manage side effects better. About 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sym…

This study looked at over 1,600 people with esophageal cancer to compare two surgical methods: a newer, less invasive technique called IVMTE and a standard approach called VME. Researchers checked how well patients recovered after surgery and how long they lived without the cance…

This study looked at whether waiting 10-12 weeks instead of the usual 4-6 weeks after chemoradiation before surgery helps patients with esophageal or gastric cardia cancer. 202 participants were randomly assigned to one of the two timing groups. The goal was to see if a longer de…