New cocktail of drugs shows promise for Hard-to-Treat stomach cancers
NCT ID NCT05394740
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested a combination of two targeted drugs (regorafenib and nivolumab) plus standard chemotherapy in 30 adults with advanced or recurrent stomach, gastroesophageal junction, or esophageal adenocarcinoma that could not be surgically removed. The goal was to see if the combination was safe and could shrink tumors. Results may help design larger studies, but the small size and lack of a comparison group mean the findings are preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
regorafenib (Stivarga) and nivolumab (Opdivo) plus chemotherapy (CapeOX or FOLFOX)
What this could lead to
If successful, this combination could offer a new treatment option for people with advanced stomach or esophageal cancer that cannot be removed by surgery.
What could go wrong
This is a small, early-phase trial (30 participants) with no control group, so results may not apply to everyone. The combination also carries risks of side effects from multiple drugs.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Cancer Center Hospital East
Kashiwa, Chiba, 277-8577, Japan