Antibiotics before endoscopy: necessary or not for cirrhosis patients?

NCT ID NCT06437964

Completed Disease control Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving antibiotics before an endoscopic procedure helps prevent fever and rebleeding in people with cirrhosis who have had variceal bleeding before. 226 patients were randomly assigned to receive the antibiotic ceftriaxone or no antibiotics before the procedure. The goal was to see if skipping antibiotics is just as safe (non-inferior) as using them.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ceftriaxone (an antibiotic)
What this could lead to: If successful, this could show that skipping antibiotics before endoscopy is safe for some cirrhosis patients, reducing unnecessary drug use.
What could go wrong: This is a small, completed trial with only 226 participants. Results may not apply to all patients, and skipping antibiotics could raise infection risk.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver esophageal varices with bleeding portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRRHOSIS, LIVER HYPERTENSION, PORTAL VARICEAL HEMORRHAGE

Contacts and locations

Locations

The 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, China

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