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Early liver shunt may reduce need for repeated fluid drains in ascites patients

NCT ID NCT04315571

Completed Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial compares two approved treatments for ascites (fluid buildup in the belly) caused by portal hypertension. One group receives large-volume paracentesis (draining fluid with a needle) plus albumin infusion, while the other gets an early TIPS procedure, which creates a new path in the liver to reduce pressure. The study measures how often paracentesis is needed and whether patients survive without needing a liver transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Gore® Viatorr® Endoprosthesis (TIPS device)
What this could lead to
If early TIPS works better than repeated fluid drainage, it could reduce the need for frequent paracentesis and improve survival without a liver transplant.
What could go wrong
This is a small, early-stage study (68 people), so results may not apply to everyone. TIPS carries risks like infection, bleeding, or worsening liver function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Ascites End Stage Liver Disease Fibrosis hepatic encephalopathy portal hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCITES HYPERTENSION, PORTAL

Contacts and locations

Locations

  • UCLA Medical Center

    Los Angeles, California, 90095, United States

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