New Dual-Action antibodies take on tough esophageal cancer
NCT ID NCT04785820
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tested two experimental drugs, lomvastomig and tobemstomig, against the standard immunotherapy nivolumab in 190 people with advanced esophageal cancer that had worsened after chemotherapy. The drugs are bispecific antibodies designed to block two immune checkpoints at once, potentially boosting the immune system's attack on cancer cells. The study compared overall survival and side effects among the three groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- bispecific antibodies (lomvastomig and tobemstomig)
- What this could lead to
- If successful, these new drugs could offer a more effective treatment option for advanced esophageal cancer that has stopped responding to standard chemotherapy.
- What could go wrong
- This is an early-phase trial with only 190 participants, and one drug arm was stopped early for strategic reasons. The results may not lead to a new approved treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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APHP - Hopital Saint Antoine
Paris, 75571, France
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Ac?badem Altunizade Hastanesi
Istanbul, Turkey (Türkiye)
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Asan Medical Center
Seoul, 05505, South Korea
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Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department
Erzurum, 25240, Turkey (Türkiye)
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Azienda Sanitaria Universitaria Integrata di Udine - PO Universitario Santa Maria della
Udine, Friuli Venezia Giulia, 33100, Italy
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Bashkirian Republican Clinical Oncology Dispensary
Ufa, Bashkortostan Republic, 450054, Russia
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Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital
Adana, 01230, Turkey (Türkiye)
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Centre Leon Berard
Lyon, 69373, France
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Centro Oncologico Riojano Integral (CORI)
La Rioja, F5300COE, Argentina
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Centrum Onkologii w Bydgoszczy
Bydgoszcz, 85-796, Poland
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Changhua Christian Hospital
Chang-hua, 500, Taiwan
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Chonnam National University Hwasun Hospital
Jeollanam-do, 58128, South Korea
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Communal Non profit Enterprise Regional Center of Oncology
Kharkiv, Kharkiv Governorate, 61070, Ukraine
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Complejo Hospitalario de Navarra
Pamplona, Navarre, 31008, Spain
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Curie Oncology
Singapore, 329563, Singapore
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Dicle Uni Medical Faculty
Diyarbakır, 10000, Turkey (Türkiye)
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Fakultni nemocnice Olomouc
Olomouc, 779 00, Czechia
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First Moscow State Medical University n.a. I.M. Sechenov
Moscow, Moscow Oblast, 119991, Russia
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Group of companies "Medci"
Moskva, Moscow Oblast, 105229, Russia
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Hopital Claude Huriez
Lille, 59037, France
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Hopital Timone Adultes
Marseille, 13385, France
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Clínic i Provincial
Barcelona, 08036, Spain
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Hospital das Clinicas - UFRGS
Porto Alegre, Rio Grande do Sul, Brazil
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ICO Rene Gauducheau
Saint-Herblain, 44805, France
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IRCCS Istituto Oncologico Veneto (IOV)
Padova, Veneto, 35128, Italy
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Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department
Malatya, 44280, Turkey (Türkiye)
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Inst. Alexander Fleming
Buenos Aires, C1426ANZ, Argentina
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Institut régional du Cancer Montpellier
Montpellier, 34298, France
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Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
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International Cancer Institute (ICI)
Eldoret, 30100, Kenya
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Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS
Meldola, Emilia-Romagna, 47014, Italy
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Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet
Szolnok, 5004, Hungary
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Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II
Krakow, 31-202, Poland
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MEDSI Clinical Hospital on Pyatnitsky Highway
Moscow, Moscow Oblast, 143422, Russia
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Masaryk?v onkologický ústav
Brno, 656 53, Czechia
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NIO im Marii Sklodowskiej-Curie
Warsaw, 02-034, Poland
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National Cancer Centre
Singapore, 168583, Singapore
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National Taiwan University Hospital
Zhongzheng Dist., 10048, Taiwan
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Nottingham City Hospital
Nottingham, NG5 1PB, United Kingdom
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Odense Universitetshospital, Onkologisk Afdeling R
Odense C, 5000, Denmark
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Ramathibodi Hospital
Bangkok, 10400, Thailand
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Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary
Sumy, 40005, Ukraine
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Rigshospitalet
København Ø, 2100, Denmark
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Seoul National University Bundang Hospital
Seongnam-si, 13605, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
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Siriraj Hospital
Bangkok, 10700, Thailand
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Songklanagarind Hospital
Songkhla, 90110, Thailand
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Szpital Morski im. PCK
Gdynia, 81-519, Poland
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Taipei Veterans General Hospital
Taipei, 112201, Taiwan
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The Aga Khan University-Kenya.
Nairobi, 00100, Kenya
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Van Yuzuncu Yil University Hospital
Van, Turkey (Türkiye)