50,000 iranians join quest to uncover esophageal cancer triggers

NCT ID NCT00450788

Completed Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing factors like diet, hot tea consumption, tobacco, opium, and genetics to find possible causes. No treatment or intervention was tested.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify key risk factors for esophageal cancer, pointing toward prevention strategies in high-risk populations.
What could go wrong: This is an observational study, not a treatment trial. It cannot prove cause and effect, and findings may not apply to other regions or groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

digestive system disorder esophageal cancer Esophageal Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER GI DISEASE

Contacts and locations

Locations

Digestive Disease Research Institute

Tehran, 14117-1313, Iran

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