Which chemo works best for esophageal cancer? new trial aims to find out

NCT ID NCT02359968

Completed Disease control Sponsor: Centre Oscar Lambret Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two chemotherapy regimens (FOLFOX and CarboP-pacliT) given with radiation before surgery for esophageal or junction cancer. 106 patients were enrolled to see which treatment leads to better tumor removal and fewer serious complications. The goal is to help doctors choose the best approach for this type of cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FOLFOX (fluorouracil, oxaliplatin, folinic acid) and CarboP-pacliT (carboplatin, paclitaxel)
What this could lead to: If this trial succeeds, it could show which chemotherapy combination works best before surgery for esophageal cancer, helping doctors choose the most effective treatment.
What could go wrong: This is a phase 2 trial with only 106 participants, so results may not apply to everyone. Both treatments have side effects, and the study may not find a clear winner.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms gastroesophageal cancer gastroesophageal junction adenocarcinoma neoplasm of esophagus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL NEOPLASMS GASTRO ESOPHAGEAL JUNCTION CANCER

Contacts and locations

Locations

CH Lyon sud

Pierre-Bénite, France
CHU Bordeaux

Bordeaux, France
Centre Eugène Marquis

Rennes, France
Centre Oscar Lambret

Lille, 59020, France
Hôpital La Timone

Marseille, France
Hôpital Nord

Marseille, France
ICM - Val d'Aurelle

Montpellier, France
ICO Paul Papin

Angers, France
ICO René Gauducheau

Saint-Herblain, France
University Hospital of Lille

Lille, 59000, France

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