New drug combo shows promise for tough stomach cancers
NCT ID NCT03008278
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two drugs, olaparib and ramucirumab, in 51 people with advanced stomach or gastroesophageal junction cancer that had spread or could not be removed. The goal was to find the best dose and see how well the combination worked. The trial is complete, and results may help guide future treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- olaparib and ramucirumab
- What this could lead to
- If successful, this combination could offer a new treatment option for advanced stomach cancer that has spread or come back.
- What could go wrong
- This is an early-phase trial with a small number of participants. The combination may not work better than existing treatments and could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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City of Hope Antelope Valley
Lancaster, California, 93534, United States
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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City of Hope Corona
Corona, California, 92882, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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City of Hope Upland
Upland, California, 91786, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437, United States
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Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385, United States
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105, United States
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Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418, United States
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Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, 06477, United States
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Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790, United States
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Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708, United States
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UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee, 37204, United States
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Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
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Yale University
New Haven, Connecticut, 06520, United States
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Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Triple chemo cocktail aims to clear deadly bowel blockages in advanced stomach cancer
- Experimental drug combo targets Hard-to-Treat GI cancers
- Home monitoring may keep cancer patients out of the ER
- New drug cocktail shows promise for tough stomach cancers
- New drug cocktail targets cancers missing key gene
- New drug cocktail aims to fight Hard-to-Treat stomach cancers