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New cocktail of drugs tested for tough esophageal cancer

NCT ID NCT05342636

Completed Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested several combinations of the immunotherapy drug pembrolizumab (Keytruda) with other drugs in 90 people with advanced esophageal cancer that had already progressed after one prior treatment. The goal was to see if these combinations are safe and can shrink tumors or slow the cancer's growth. The trial is now complete, and results will help decide which combinations to study further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Pembrolizumab (Keytruda) plus other drugs (favezelimab, MK-4830, lenvatinib, irinotecan, chemotherapy)
What this could lead to
If successful, this could point toward new treatment options for advanced esophageal cancer that has stopped responding to standard therapy.
What could go wrong
This is an early-phase trial with only 90 participants, so results may not apply to all patients. The drug combinations may cause side effects and may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 Esophageal Neoplasms esophageal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL SQUAMOUS CELL CARCINOMA (ESCC)

Contacts and locations

Locations

  • Acibadem Altunizade Hospital-Oncology ( Site 1407)

    Üsküdar / İstanbul, Istanbul, 34662, Turkey (Türkiye)

  • Adana Medical Park Seyhan Hastanesi-Medikal Onkoloji ( Site 1417)

    Adana, 01140, Turkey (Türkiye)

  • Aichi Cancer Center Hospital ( Site 1702)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Akdeniz Universitesi Hastanesi-Medical Oncology ( Site 1410)

    Antalya, 07059, Turkey (Türkiye)

  • Ankara City Hospital-Medical Oncology ( Site 1405)

    Ankara, 06800, Turkey (Türkiye)

  • Asan Medical Center-Department of Oncology ( Site 1901)

    Seoul, 05505, South Korea

  • Atatürk Üniversitesi-onkoloji ( Site 1416)

    Erzurum, 25070, Turkey (Türkiye)

  • Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan ( Site 1104)

    Brest, Finistere, 29200, France

  • Chang Gung Medical Foundation-Linkou Branch ( Site 2006)

    Taoyuan, 333, Taiwan

  • Chang Gung Memorial Hospital at Kaohsiung ( Site 2003)

    Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

  • Charité Campus Virchow-Klinikum-Klinik Hämatologie Onkologie Tumorimmunologie ( Site 2804)

    Berlin, 13353, Germany

  • China Medical University Hospital ( Site 2007)

    Taichung, 404332, Taiwan

  • Chulalongkorn University ( Site 2104)

    Bangkok, Bangkok, 10330, Thailand

  • Clínica las Condes ( Site 2403)

    Santiago, Region M. de Santiago, 7591047, Chile

  • FALP-UIDO ( Site 2400)

    Santiago, Region M. de Santiago, 7500921, Chile

  • Faculty of Medicine Siriraj Hospital ( Site 2102)

    Bangkok, Bangkok, 10700, Thailand

  • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1200)

    Milan, Lombardy, 20133, Italy

  • Hacettepe Universite Hastaneleri-oncology hospital ( Site 1402)

    Ankara, 06230, Turkey (Türkiye)

  • Hopital Claude Huriez - CHU de Lille ( Site 1100)

    Lille, Nord, 59037, France

  • Hospital Nossa Senhora da Conceição ( Site 2301)

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hôpitaux Universitaires de Genève (HUG) ( Site 2702)

    Geneva, Canton of Geneva, 1211, Switzerland

  • I.E.U. Medical Point Hastanesi-Oncology ( Site 1406)

    Izmir, Karsiyaka, İzmir, 009035575, Turkey (Türkiye)

  • ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 2300)

    São Paulo, São Paulo, 01246-000, Brazil

  • Institut für Klinisch Onkologische Forschung-Klink für Onkologie und Hämatologie ( Site 2801)

    Frankfurt am Main, Hesse, 60488, Germany

  • Istituto Europeo di Oncologia IRCCS-Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative (

    Milan, 20141, Italy

  • Istituto Oncologico Veneto IRCCS ( Site 1205)

    Padova, 35128, Italy

  • Kantonsspital Graubünden-Medizin ( Site 2700)

    Chur, Kanton Graubünden, 7000, Switzerland

  • Liga Norte Riograndense Contra o Câncer ( Site 2303)

    Natal, Rio Grande do Norte, 59062-000, Brazil

  • Memorial Ankara Hastanesi-Medical Oncology ( Site 1408)

    Ankara, 06520, Turkey (Türkiye)

  • National Cancer Center Hospital ( Site 1700)

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East ( Site 1701)

    Kashiwa, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital ( Site 2001)

    Tainan, 704, Taiwan

  • National Taiwan University Hospital ( Site 2000)

    Taipei, 10002, Taiwan

  • National University Hospital ( Site 1800)

    Singapore, South West, 119074, Singapore

  • Oslo universitetssykehus, Radiumhospitalet ( Site 2501)

    Oslo, 0310, Norway

  • Ospedale San Raffaele-Oncologia Medica ( Site 1206)

    Milan, Lombardy, 20132, Italy

  • Pitie Salpetriere University Hospital ( Site 1102)

    Paris, Orne, 75013, France

  • Saitama Prefectural Cancer Center ( Site 1703)

    Ina-machi, Saitama, 362-0806, Japan

  • Samsung Medical Center-Division of Hematology/Oncology ( Site 1900)

    Seoul, 06351, South Korea

  • Shizuoka Cancer Center ( Site 1704)

    Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan

  • Songklanagarind hospital ( Site 2105)

    Hat Yai, Changwat Songkhla, 90110, Thailand

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1403)

    Istanbul, 34722, Turkey (Türkiye)

  • Taichung Veterans General Hospital-Radiation Oncology ( Site 2008)

    Taichung, 407, Taiwan

  • Taipei Veterans General Hospital ( Site 2005)

    Taipei, 112, Taiwan

  • Universitaetsklinikum Carl Gustav Carus Dresden-Medical Dept I - Medical Oncology ( Site 2806)

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Duesseldorf ( Site 2802)

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

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