Could a prebiotic syrup help tame stubborn heartburn?
NCT ID NCT05556824
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether a prebiotic syrup called MHS-1031 (PIMO) can increase heartburn-free days when added to standard proton pump inhibitor (PPI) therapy for people with GERD. About 247 adults who still have heartburn despite taking PPIs will receive either the syrup or a placebo for 8 weeks. The study tracks how often heartburn occurs and how severe it is using a daily electronic diary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MHS-1031 (a prebiotic syrup called Panosyl-isomaltooligosaccharide)
What this could lead to
If it works, this could offer a new add-on option to reduce heartburn for people with GERD who still have symptoms despite taking standard acid-reducing medication.
What could go wrong
This is an early Phase 2 trial, so results are not yet proven. The improvement may be small or no better than placebo, and the study only lasts 8 weeks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A Positive Clinical Research
Miami, Florida, 33186, United States
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A and U Family Medicine (NCR)
Sugar Land, Texas, 77479, United States
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Advanced Gastroenterology Associates LLC
Palm Harbor, Florida, 34684, United States
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Angel City Research
Los Angeles, California, 90010, United States
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Charlottesville Medical Research Center
Charlottesville, Virginia, 22911, United States
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Digestive Disease and Liver Specialists
Norfolk, Virginia, 23502, United States
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Elite Clinical Studies LLC
Phoenix, Arizona, 85018, United States
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EmVenio-Georgia (EMGA)
Atlanta, Georgia, 30345, United States
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GI Research Partners, LLC
Richmond, Virginia, 23236, United States
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Gastroenterology Associates of Western Michigan PLC (WMCR)
Wyoming, Michigan, 49519, United States
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Health Synergy Clinical Research
West Palm Beach, Florida, 33407, United States
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M3 Wake Research (CPOR)
Raleigh, North Carolina, 27612, United States
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SMS Clinical Research (SMSR)
Mesquite, Texas, 75149, United States
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University of Virginia Health System
Charlottesville, Virginia, 22908, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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WR-Mount Vernon Clinical Research (MVCR)
Sandy Springs, Georgia, 30328, United States
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West Palm Quality Research (WPQR)
West Palm Beach, Florida, 33407, United States
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Wr-Msra, Llc
Lake City, Florida, 32055, United States