Could a prebiotic syrup help tame stubborn heartburn?

NCT ID NCT05556824

Completed Symptom relief Sponsor: Microbiome Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This Phase 2 trial tests whether a prebiotic syrup called MHS-1031 (PIMO) can increase heartburn-free days when added to standard proton pump inhibitor (PPI) therapy for people with GERD. About 247 adults who still have heartburn despite taking PPIs will receive either the syrup or a placebo for 8 weeks. The study tracks how often heartburn occurs and how severe it is using a daily electronic diary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MHS-1031 (a prebiotic syrup called Panosyl-isomaltooligosaccharide)
What this could lead to: If it works, this could offer a new add-on option to reduce heartburn for people with GERD who still have symptoms despite taking standard acid-reducing medication.
What could go wrong: This is an early Phase 2 trial, so results are not yet proven. The improvement may be small or no better than placebo, and the study only lasts 8 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease Heartburn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL REFLUX

Contacts and locations

Locations

A Positive Clinical Research

Miami, Florida, 33186, United States
A and U Family Medicine (NCR)

Sugar Land, Texas, 77479, United States
Advanced Gastroenterology Associates LLC

Palm Harbor, Florida, 34684, United States
Angel City Research

Los Angeles, California, 90010, United States
Charlottesville Medical Research Center

Charlottesville, Virginia, 22911, United States
Digestive Disease and Liver Specialists

Norfolk, Virginia, 23502, United States
Elite Clinical Studies LLC

Phoenix, Arizona, 85018, United States
EmVenio-Georgia (EMGA)

Atlanta, Georgia, 30345, United States
GI Research Partners, LLC

Richmond, Virginia, 23236, United States
Gastroenterology Associates of Western Michigan PLC (WMCR)

Wyoming, Michigan, 49519, United States
Health Synergy Clinical Research

West Palm Beach, Florida, 33407, United States
M3 Wake Research (CPOR)

Raleigh, North Carolina, 27612, United States
SMS Clinical Research (SMSR)

Mesquite, Texas, 75149, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
WR-Mount Vernon Clinical Research (MVCR)

Sandy Springs, Georgia, 30328, United States
West Palm Quality Research (WPQR)

West Palm Beach, Florida, 33407, United States
Wr-Msra, Llc

Lake City, Florida, 32055, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.