New drug cocktail shows promise against tough esophageal cancer

NCT ID NCT06010303

Completed Disease control Sponsor: BeiGene Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an experimental drug called LBL-007 to standard immunotherapy and chemotherapy helps shrink tumors better in people with advanced esophageal cancer that cannot be surgically removed. About 118 participants received either the three-drug combo or the standard two-drug combo as their first treatment. The main goal was to see how many patients had their tumors shrink significantly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LBL-007 (Alcestobart) plus tislelizumab and chemotherapy
What this could lead to: If successful, this combination could become a new first-line treatment option that shrinks tumors more effectively in people with advanced esophageal cancer.
What could go wrong: This is a Phase 2 trial with only 118 participants, so results are preliminary. The added drug may not improve outcomes and could increase side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms esophageal squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESOPHAGEAL CANCER ESOPHAGEAL SQUAMOUS CELL CARCINOMA ESOPHAGEAL SQUAMOUS CELL CARCINOMA BY AJCC V8 STAGE

Contacts and locations

Locations

Anhui Provincial Hospital

Hefei, Anhui, 230000, China
Anyang Cancer Hospital

Anyang, Henan, 455001, China
Changhua Christian Hospital

Changhua, 50006, Taiwan
China Medical University Hospital

Taichung, 40447, Taiwan
Chonnam National University Hwasun Hospital

HwasunGun, Jeollanam-do, 58128, South Korea
Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
General Hospital of Ningxia Medical University

Yinchuan, Ningxia, 750004, China
Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, 150000, China
Henan Cancer Hospital

Zhengzhou, Henan, 450000, China
Hrh Princess Maha Chakri Sirindhorn Medical Center (Srinakharinwirot University)

Ongkharak, 26120, Thailand
Hunan Cancer Hospital

Changsha, Hunan, 410013, China
Kaohsiung Medical University Chung Ho Memorial Hospital

Kaohsiung City, 807, Taiwan
Lanzhou University Second Hospital

Lanzhou, Gansu, 730030, China
Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School

Nanjing, Jiangsu, 210008, China
Nantong Tumor Hospital Branch North

Nantong, Jiangsu, 226000, China
Nanyang Central Hospital

Nanyang, Henan, 473000, China
National Cancer Center

Goyang-si, Gyeonggi-do, 10408, South Korea
National Taiwan University Hospital

Taipei, 10048, Taiwan
Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China
Phramongkutklao Hospital

Ratchathewi, 10400, Thailand
Ramathibodi Hospital Mahidol University

Bangkok, 10400, Thailand
Seoul National University Hospital

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, Seoul Teugbyeolsi, 03722, South Korea
Shandong Cancer Hospital

Jinan, Shandong, 250117, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

Chengdu, Sichuan, 610071, China
Sichuan Cancer Hospital and Institute

Chengdu, Sichuan, 610041, China
Siriraj Hospital

Bangkok, 10700, Thailand
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China
The Catholic University of Korea, Seoul St Marys Hospital

Seoul, Seoul Teugbyeolsi, 06591, South Korea
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230000, China
The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, Henan, 453100, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Peoples Hospital of Changzhou

Changzhou, Jiangsu, 213000, China
The Second Affiliated Hospital of Shandong First Medical University

Taian, Shandong, 271099, China
The Tumor Hospital Affiliated to Guangxi Medical University

Nanning, Guangxi, 530021, China
Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, 300060, China

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