Does waiting longer for surgery after chemoradiation improve esophageal cancer outcomes?

NCT ID NCT02415101

Completed Knowledge-focused Sponsor: Karolinska University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether waiting 10-12 weeks instead of the usual 4-6 weeks after chemoradiation before surgery helps patients with esophageal or gastric cardia cancer. 202 participants were randomly assigned to one of the two timing groups. The goal was to see if a longer delay leads to a better tumor response and fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: resective surgery
What this could lead to: If a longer wait improves tumor response and reduces complications, it could lead to better surgical outcomes for esophageal cancer patients.
What could go wrong: This is a completed study comparing two timing schedules, not a new treatment. The results may not change standard practice if no clear benefit is found.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma carcinoma of esophagus esophageal cancer Esophageal Neoplasms gastric cardia carcinoma squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER OF THE ESOPHAGUS

Contacts and locations

Locations

Department of Surgery Gastrocentrum Karolinska Univeristy Hospital

Stockholm, 14186, Sweden

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