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New GERD drug aims to heal esophagus damage when standard treatments fail

NCT ID NCT05055128

Completed Disease control Sponsor: Cinclus Pharma Holding AB Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial compares X842 with the common medication lansoprazole to see which better heals the esophagus after 4 weeks, and tracks symptoms during a follow-up period. The goal is to find the right dose for future larger studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
X842
What this could lead to
If successful, X842 could offer a new treatment option for people with severe GERD-related esophagitis that hasn't healed with standard medications.
What could go wrong
This is an early phase 2 dose-finding study, so results may not confirm effectiveness. Side effects are still being evaluated, and the drug may not outperform existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophagitis peptic esophagitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EROSIVE ESOPHAGITIS

Contacts and locations

Locations

  • 2-nd MHAT

    Sofia, Sofia, 1202, Bulgaria

  • A. Aladashvili clinic LLC

    Tbilisi, K'alak'i T'bilisi, 0102, Georgia

  • Bekes Megyei Kozponti Korhaz, Dr.Rethy Pal Tagkorhaz

    Békéscsaba, Bekes County, 5600, Hungary

  • Centrum Medyczne Melita Medical

    Wroclaw, Lower Silesian Voivodeship, 50-449, Poland

  • ClinExpert Kft.

    Budapest, Pest County, 1032, Hungary

  • DCC XIV Sofia

    Sofia, Sofia-Grad, 1404, Bulgaria

  • DCC XIV Sofia

    Sofia, Sofia-Grad, 1408, Bulgaria

  • DCC-1 Sliven

    Plovdiv, Plovdiv, 4002, Bulgaria

  • Diagnostive Consultative Center-1 Sliven

    Sliven, Sliven, 8800, Bulgaria

  • ETG Skierniewice

    Skierniewice, 96-100, Poland

  • ETG Zamosc

    Zamość, 22-400, Poland

  • Emergency Cardiology Center named by acad. G. Chapidze

    Tbilisi, K'alak'i T'bilisi, Georgia

  • EuroMediCare Szpital Specjalistyczny z Przychodnia

    Wroclaw, 50-449, Poland

  • EuroMediCare Szpital Specjalistyczny z Przychodnia

    Wroclaw, 54-144, Poland

  • Genesis Clinical Research - Tampa

    Tampa, Florida, 33614, United States

  • KNP "Odeska oblasna klinichna likarnia" Odeskoi oblasnoi rady"

    Odesa, Odesa Oblast, 65025, Ukraine

  • KU "6-A miska klinichna likarnia"

    Zaporizhzhia, Zaporizhzhia Oblast, 69035, Ukraine

  • LTD Israeli-Georgian Medical Research Clinic "Helsicore"

    Tbilisi, K'alak'i T'bilisi, 0112, Georgia

  • LTD TSMU and Ingorokva High Medical Technology University Clinic

    Tbilisi, K'alak'i T'bilisi, 0141, Georgia

  • LTD"Brothers"

    Batumi, Adjara, 6010, Georgia

  • MHAT "Kaspela"

    Plovdiv, Plovdiv, 4002, Bulgaria

  • MHAT "Sveti Ivan Rilski" - Sofia

    Sofia, Sofia, 1431, Bulgaria

  • Medical Center "Biomed 99" Ltd

    Vidin, 3700, Bulgaria

  • Medical Center Excelsior

    Sofia, Sofia, 1407, Bulgaria

  • Medical Center Excelsior

    Sofia, Sofia-Grad, 1233, Bulgaria

  • Medical Center Hera - Gastroenterology office

    Sliven, Sliven, 8800, Bulgaria

  • Medical Center Hera - Gastroenterology office

    Sofia, Sofia, 1510, Bulgaria

  • Medical Center Medconsult Pleven

    Pleven, Pleven, 5800, Bulgaria

  • Medical Center New Rehabilitation Center EOOD

    Stara Zagora, Stara Zagora, 6003, Bulgaria

  • Medical Center Prolet EOOD

    Rousse, Ruse, 7000, Bulgaria

  • Medical Centre Asklepii

    Dupnitsa, Dupnitsa, 2600, Bulgaria

  • Medychnyi Tsentr TOV "KHELS KLINIK" - viddil Gasrtroenterology, Hepatology and Endocrinology

    Vinnytsia, Vinnytsia Oblast, 21009, Ukraine

  • Mhat "Hristo Botev"

    Vratsa, Vratsa, 3000, Bulgaria

  • NZOZ "Centrum Medyczne KERMED"

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-681, Poland

  • Oblasna komunalna ustanova "Chernivetska oblasna klinichna likarnia"

    Chernivtsi, Chernivtsi Oblast, 58001, Ukraine

  • Oswiecimskie Centrum Badan Klinicznych Medicome Sp. z o.o.

    Oświęcim, 32-600, Poland

  • Pannonia Maganorvosi Centrum Kft

    Budapest, Budapest, H-1136, Hungary

  • ResTrial GastroEndo s.r.o.

    Prague, 143 00, Czechia

  • Szegedi Tudomanyegyetem Általános Orvostudományi Kar

    Szeged, Csongrád megye, H-6725, Hungary

  • Szpital Zakonu Bonifratrow Sw. Jana Bozego w Lodzi

    Lodz, Lódzkie, 90-302, Poland

  • Twoja Przychodnia - Szczecinskie Centrum Medyczne

    Szczecin, 71-270, Poland

  • Zvezdara University Medical Center

    Belgrade, Belgrade, 11000, Serbia

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