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ALS patients get early access to potential slowing drug

NCT ID NCT06743776

AVAILABLE Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This program offers the drug ibudilast (MN-166) to people with ALS who cannot join other clinical trials. Participants take the drug by mouth, starting at a lower dose and increasing. The goal is to see if ibudilast can slow the progression of ALS. The program also collects blood samples to study biomarkers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ibudilast (MN-166)
What this could lead to
If it works, this could help slow the progression of ALS in patients who cannot join other clinical trials.
What could go wrong
This is an expanded access program, not a formal trial, so results are less certain. Ibudilast may not slow ALS for everyone and could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS

Contacts and locations

Locations

  • Augusta University

    AVAILABLE

    Augusta, Georgia, 30912, United States

  • Duke University

    AVAILABLE

    Durham, North Carolina, 27705, United States

    Contact Email: •••••@•••••

  • Hennepin Healthcare Research Institute

    AVAILABLE

    Minneapolis, Minnesota, 55415, United States

  • Hospital for Special Care

    AVAILABLE

    New Britain, Connecticut, 06053, United States

  • Indiana University - IU Health Neuroscience Center

    AVAILABLE

    Indianapolis, Indiana, 46202, United States

  • Lehigh Valley Health Network

    AVAILABLE

    Allentown, Pennsylvania, 18103, United States

  • Mayo Clinic

    AVAILABLE

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic

    AVAILABLE

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic

    AVAILABLE

    Rochester, Minnesota, 55905, United States

  • Nova Southeastern University

    AVAILABLE

    Davie, Florida, 33314, United States

  • SUNY Upstate Medical University

    AVAILABLE

    Syracuse, New York, 13210, United States

  • Semmes Murphey Foundation

    AVAILABLE

    Memphis, Tennessee, 38120, United States

  • UCI Health

    AVAILABLE

    Orange, California, 92868, United States

  • University of California, San Francisco

    AVAILABLE

    San Francisco, California, 94143, United States

  • University of Virginia

    AVAILABLE

    Charlottesville, Virginia, 22908, United States

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