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Scientists hunt for biological clues to how ALS drug affects the body

NCT ID NCT04259255

Completed Knowledge-focused Sponsor: Shionogi Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study follows about 74 adults with ALS who have already decided to take the drug Edaravone (Radicava). Researchers collect blood and urine samples over 24 weeks to measure various biomarkers—molecules that might show how the drug affects oxidative stress, inflammation, and nerve damage. The goal is to find measurable biological signs that could help track the drug's effects in future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Edaravone (Radicava)
What this could lead to
If successful, this study could identify biological markers that help measure how Edaravone works in ALS, potentially guiding future treatment monitoring.
What could go wrong
This is an observational study focused on biomarkers, not on proving the drug works. It may not lead to new treatments or change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis motor neuron disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS AMYOTROPHIC LATERAL SCLEROSIS

Contacts and locations

Locations

  • Barrow Neurological Institute

    Phoenix, Arizona, 85013, United States

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Jefferson Weinberg ALS Center

    Philadelphia, Pennsylvania, 19107, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21205, United States

  • Las Vegas Clinic

    Las Vegas, Nevada, 89145, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02214, United States

  • Mayo Clinic Florida

    Jacksonville, Florida, 32224, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Mercy Health

    Grand Rapids, Michigan, 49503, United States

  • Neurology Associates, P.C.

    Lincoln, Nebraska, 68506, United States

  • OhioHealth

    Columbus, Ohio, 43215, United States

  • SunnyBrook Research Institute

    Toronto, Ontario, M4N 3M5, Canada

  • Temple University Lewis Katz School of Medicine

    Philadelphia, Pennsylvania, 19140, United States

  • UC Davis Health

    Sacramento, California, 95817, United States

  • UCLA Als Clinic

    Los Angeles, California, 90024, United States

  • University of California, San Francisco

    San Francisco, California, 94417, United States

  • University of Colorado

    Denver, Colorado, 80309, United States

  • University of Florida, Jacksonville -Neurology Research Department

    Jacksonville, Florida, 32209, United States

  • University of South Florida

    Tampa, Florida, 33612, United States

  • University of Utah

    Salt Lake City, Utah, 84112, United States

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