ALS

This early-stage trial is testing the safety of an experimental drug called siplizumab in 48 adults recently diagnosed with ALS (Lou Gehrig's disease). Researchers will monitor patients for one year to see how their bodies handle the drug and check for side effects. The study wil…

This study aims to find out if starting noninvasive breathing support (NIV) for ALS patients with chronic breathing problems can be done just as well at home as in the hospital. It will compare how much patients use the device, how well their blood gases improve, and the costs of…

This program provides the experimental drug ibudilast to people with ALS who cannot join regular clinical trials. It aims to see if the drug can slow down ALS progression while studying blood markers of nerve damage. The program is open to adults diagnosed with ALS who meet speci…

This early-stage trial is testing whether a special ultrasound helmet can safely and temporarily open the brain's protective barrier. The goal is to help deliver an immune therapy (IVIg) directly to the brain areas affected by ALS. Six participants will receive the therapy, with …

This early-stage study is testing the safety of a new drug called AMX0114 for people with ALS. The drug is given as an injection into the spinal fluid in the lower back. Researchers will monitor 48 adults with early-stage ALS to see how their bodies handle the treatment and check…

This study is testing a small brain implant that reads movement signals from the brain. The goal is to help people who are paralyzed from conditions like spinal cord injury, stroke, or ALS control a tablet computer for communication. The main focus is on checking if the implant i…

This study is testing whether two types of breathing exercises can help people with ALS cough more effectively and breathe better. Up to 39 participants will learn the exercises and practice them at home with weekly video check-ins from a therapist. Researchers will measure cough…

This study aims to better understand brain inflammation in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will use PET scans to measure specific inflammation markers in the brains of 184 participants, including both patients and healthy volunteers.…

This study aims to collect detailed health information from 5,000 people living with ALS and related motor neuron diseases. Participants will have their routine clinic visit data, like symptoms and test results, securely stored in a central research database. The goal is to creat…

This study aims to understand how the brain processes imagined Mandarin Chinese speech by recording electrical signals directly from the brain's surface. It involves patients who are already having brain surgery for conditions like epilepsy or tumors, or those with severe speech …

This study aims to understand how ALS begins and progresses in people who carry a gene for the disease but don't yet have symptoms. Researchers will follow 300 healthy family members of ALS patients over time, offering genetic counseling and testing. The goal is to gather informa…