ALS

This program offers the drug ibudilast to people with ALS who cannot join other clinical trials. The goal is to see if it can slow down the disease. Participants must meet specific criteria, such as being over 18 and diagnosed with ALS.

This study tests a brain-computer interface (iBCI) that reads movement-related brain signals to let people with severe paralysis (from ALS, spinal cord injury, or brainstem stroke) control a tablet computer just by thinking. The goal is to restore fast, natural communication usin…

This early-stage trial tests a drug called siplizumab in 48 adults recently diagnosed with ALS. The main goal is to check if the drug is safe and how the body processes it. Researchers will also look at how the drug affects immune cells and ALS symptoms over 52 weeks.

This early study is testing a device called a brain-computer interface that is implanted into a blood vessel in the brain. It is designed to help people with ALS who have weakness in both arms control external devices, like a computer, using only their thoughts. The study will in…

This early-stage study tests whether a special helmet that uses sound waves can safely open a temporary window in the brain's protective barrier. This would allow an anti-inflammatory medicine (IVIg) to reach the motor cortex, the area controlling movement that is damaged in ALS.…

This study tests a brain-computer interface (BCI) implant for people with ALS or motor neuron disease who have weakness in both arms. The device aims to let them control computers or other devices just by thinking. The main goal is to check safety, such as serious side effects or…

This early-stage study tests an experimental drug, AMX0114, in 48 adults with ALS. The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body. This is a first step to see if the drug might help control the diseas…

This study looks at whether people with ALS and chronic breathing problems can start using a noninvasive ventilator (a mask that helps them breathe) at home instead of in the hospital. Researchers will compare how well patients use the machine and how much it costs. The goal is t…

This study tests two breathing exercises together in people with ALS to see if they can improve cough strength and lung function. About 34 participants will practice lung volume recruitment and expiratory muscle strength training. The goal is to ease breathing problems, reduce co…

This study follows 300 family members of people with inherited ALS who do not yet have symptoms. Researchers provide genetic counseling and testing, then track participants yearly to see when and how early signs of the disease appear. The goal is to gather information that will h…

This study tests whether high-density brain recordings can decode Mandarin Chinese speech features, including tone, from imagined speech. About 50 adults with brain conditions like epilepsy or tumors will have temporary electrodes placed during surgery, and 10 people with severe …

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other similar diseases. Researchers want to see if inflammation levels are higher in these patients compared to healthy volunteers. Participants will have MRI…

This early-stage study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will part…

This study is building a large database of health information from up to 5,000 people with ALS and other motor neuron diseases. Participants attend regular clinic visits where researchers record their symptoms, test results, and disease progression. The de-identified data is then…