Can we stop ALS before it starts? new study tracks families with genetic risk

NCT ID NCT03865420

Recruiting now Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study enrolls family members of people with inherited ALS who do not yet have symptoms. Participants receive genetic counseling and testing, and are followed yearly to track when and how symptoms might appear. The goal is to gather information that could one day lead to treatments to prevent or slow ALS.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help scientists develop treatments to prevent or delay ALS in people who carry genetic mutations.
What could go wrong: This is an observational study, not a treatment trial. It may take years to gather enough data, and findings may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

frontotemporal dementia with motor neuron disease amyotrophic lateral sclerosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS

Contacts and locations

Locations

Columbia University
RECRUITING

New York, New York, 10032, United States

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