Scientists hunt for genes behind mysterious heart artery tears

NCT ID NCT01427179

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find genetic mutations that cause spontaneous coronary artery dissection (SCAD), a condition where arteries in the heart tear without warning. Researchers will analyze DNA from 2000 people diagnosed with SCAD, as well as their relatives. The goal is to identify inherited or new gene defects that may explain why some people develop this rare but serious heart problem.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify genetic causes of SCAD, potentially leading to better screening or prevention strategies for at-risk individuals.
What could go wrong: This is an observational study, not a treatment trial. Finding a clear genetic cause is uncertain, and even if found, it may not lead to immediate therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic spontaneous coronary artery dissection short chain acyl-CoA dehydrogenase deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCAD SPONTANEOUS CORONARY ARTERY DISSECTION

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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