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Heart attack without blockage: trial tests gentler blood thinners for SCAD

NCT ID NCT07683923

Not yet recruiting Disease control Sponsor: Universitätsklinikum Hamburg-Eppendorf Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in the artery wall, so strong blood thinners might worsen bleeding. The study compares 3 months of a single drug versus 3 months of two drugs followed by 9 months of one drug, tracking heart events over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Acetylsalicylic acid (ASA) and clopidogrel
What this could lead to
If successful, this could establish a safer, more effective antiplatelet regimen for SCAD patients, reducing heart complications without worsening vessel bleeding.
What could go wrong
This is a Phase 4 trial, but SCAD is rare and understudied; results may not apply to all patients, and the less intensive strategy might not prevent clots as well.

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Conditions

The condition(s) this trial relates to.

acute chest syndrome acute coronary syndrome idiopathic spontaneous coronary artery dissection short chain acyl-CoA dehydrogenase deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACS (ACUTE CORONARY SYNDROME) SCAD

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Cardiology and Department of Medical and Health Sciences, Linköping University

    Linköping, SE-581 83, Sweden

    Contact Email: •••••@•••••

  • Division of Cardiology, St. Antonius Hospital

    Nieuwegein, 3435 CM, Netherlands

    Contact Email: •••••@•••••

  • Division of Cardiology, Vancouver General Hospital, University of British Columbia

    Vancouver, British Columbia, V5Z 1M9, Canada

    Contact Email: •••••@•••••

  • University Hospitals of Leicester NHS Trust

    Leicester, LE1 5WW, United Kingdom

    Contact Email: •••••@•••••

  • University Medical Center Hamburg-Eppendorf

    Hamburg, Free and Hanseatic City of Hamburg, 20246, Germany

    Contact Email: •••••@•••••

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