Opioid's impact on diaphragm strength under the microscope
NCT ID NCT05856136
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the opioid fentanyl affects the diaphragm, the main muscle used for breathing. Researchers will give different doses of fentanyl to 69 adults having leg surgery and use ultrasound to measure diaphragm strength. The goal is to understand how opioids might weaken breathing, which could help prevent complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fentanyl
- What this could lead to
- If successful, this could help doctors understand how opioids affect breathing muscles, leading to safer dosing and reduced respiratory complications.
- What could go wrong
- This is a small, early-phase study in a specific surgical population, so results may not apply to everyone. It only measures short-term effects, not long-term safety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RESPIRATORY COMPLICATION are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Mayo Clinic Minnesota
RECRUITINGRochester, Minnesota, 55905, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can 3D motion capture reveal hidden breathing problems after esophageal cancer surgery?
- Heartbeat clues may flag surgery risks in children
- Does a stomach tube prevent breathing problems in babies with pyloric stenosis?
- Common steroid could shield lungs after surgery, but study pulled
- Ultrasound tool may Fine-Tune breathing therapy in hospital patients
- Ear zap might help stroke patients breathe easier