Opioid's impact on diaphragm strength under the microscope
NCT ID NCT05856136
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the opioid fentanyl affects the diaphragm, the main muscle used for breathing. Researchers will give different doses of fentanyl to 69 adults having leg surgery and use ultrasound to measure diaphragm strength. The goal is to understand how opioids might weaken breathing, which could help prevent complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fentanyl
What this could lead to
If successful, this could help doctors understand how opioids affect breathing muscles, leading to safer dosing and reduced respiratory complications.
What could go wrong
This is a small, early-phase study in a specific surgical population, so results may not apply to everyone. It only measures short-term effects, not long-term safety.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Minnesota
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••