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Could a common mushroom help fight breast cancer? new trial investigates

NCT ID NCT06450873

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether turkey tail mushroom extract can slow or shrink estrogen receptor-positive, HER2-negative breast cancer in post-menopausal women. Forty participants will take the supplement between diagnosis and surgery, and researchers will measure changes in a tumor growth marker called Ki-67. The study builds on earlier evidence suggesting these mushrooms may have anti-cancer effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Turkey tail mushroom extract (Coriolus versicolor)
What this could lead to
If it works, this could point toward a natural supplement that helps shrink tumors or improve outcomes in certain breast cancers before surgery.
What could go wrong
This is a small, early-phase pilot study with only 40 participants. It measures a biomarker (Ki-67), not survival or cure, so results may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

estrogen-receptor positive breast cancer Her2-receptor negative breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESTROGEN RECEPTOR-POSITIVE BREAST CARCINOMA HER2-NEGATIVE BREAST CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

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