Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a vaginal swab detect multiple cancers? mayo clinic launches major study

NCT ID NCT05051722

Recruiting now Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to develop a screening test that uses a vaginal swab and blood sample to find DNA markers for endometrial, ovarian, and cervical cancers. Researchers at Mayo Clinic will enroll over 3,000 women to see if the test can accurately detect these cancers at an early stage. The goal is to create a simple, non-invasive tool that could catch gynecologic cancers sooner.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Methylated DNA markers and high-risk human papilloma virus (HR-HPV) detection in vaginal fluid and blood
What this could lead to
If successful, this could lead to a simple, non-invasive screening test that detects multiple gynecologic cancers early, potentially improving survival rates.
What could go wrong
This is a Phase II biomarker study, not a treatment trial. The test may not prove accurate enough in larger, diverse populations, and false positives or negatives are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADNEXAL MASS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atypical endometrial hyperplasia cervical cancer cervical intraepithelial neoplasia dysplasia of cervix endometrial cancer Endometrial Hyperplasia endometrium neoplasm ovarian cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADNEXAL MASS ATYPICAL ENDOMETRIAL HYPERPLASIA CERVICAL CANCER CERVICAL DYSPLASIA ENDOMETRIAL CANCER OVARIAN CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Altru Health System

    RECRUITING

    Grand Forks, North Dakota, 58206, United States

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Genoma Research, Inc.

    RECRUITING

    Miami, Florida, 33173, United States

  • Mayo Clinic

    RECRUITING

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic Health System - Northwest Wisconsin

    RECRUITING

    Eau Claire, Wisconsin, 54703, United States

  • Mayo Clinic Health System - Southwest Wisconsin

    RECRUITING

    La Crosse, Wisconsin, 54601, United States

  • Medical Colleagues of Texas, LLP

    RECRUITING

    Katy, Texas, 77450, United States

  • Medical College of Wisconsin

    ACTIVE_NOT_RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • My GYN Care

    ACTIVE_NOT_RECRUITING

    Miami, Florida, 33156, United States

  • Ochsner Clinic Foundation

    RECRUITING

    New Orleans, Louisiana, 70121, United States

  • Orlando Health

    RECRUITING

    Orlando, Florida, 32806, United States

  • Piedmont Healthcare

    RECRUITING

    Atlanta, Georgia, 30318, United States

  • Providea Health Partners, LLC

    ACTIVE_NOT_RECRUITING

    Evergreen Park, Illinois, 60805, United States

  • Sarasota Memorial Health Care System

    RECRUITING

    Sarasota, Florida, 34239, United States

  • Signature Women's Healthcare, LLC

    ACTIVE_NOT_RECRUITING

    Pembroke Pines, Florida, 33029, United States

  • The Woman's Health Pavilion

    RECRUITING

    Howard Beach, New York, 11414, United States

  • The Woman's Health Pavilion

    RECRUITING

    Westbury, New York, 11590, United States

  • Total Women's Care of the Heights

    RECRUITING

    Houston, Texas, 77018, United States

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Mississippi Medical Center

    RECRUITING

    Jackson, Mississippi, 39213, United States

  • Valley OB-GYN Clinic

    RECRUITING

    Saginaw, Michigan, 48602, United States

  • Virginia Commonwealth University/ Massey Cancer Center

    RECRUITING

    Richmond, Virginia, 23219, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.