Could a common ED drug help fontan hearts? new trial aims to find out
NCT ID NCT05206955
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether tadalafil, a drug that relaxes blood vessels, can improve blood flow and protect organs in adults who had Fontan surgery for a single-ventricle heart defect. About 80 participants will receive either tadalafil or a placebo daily for a year. Researchers will measure changes in blood vessel function, liver stiffness, kidney function, and exercise capacity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tadalafil
What this could lead to
If it works, this could lead to a new treatment to improve blood flow and protect the liver, kidneys, and exercise ability in people living with Fontan circulation.
What could go wrong
This is a phase 3 trial, but tadalafil has not been proven effective for this condition before. It may not improve outcomes, and side effects like headache or muscle aches are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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