Blood test could help throat cancer patients get less radiation
NCT ID NCT05541016
First seen Sep 30, 2025 · Last updated Jun 22, 2026 · Updated 29 times
Summary
This phase II trial tests whether a blood test that detects HPV DNA can help doctors decide the right amount of radiation for people with HPV-positive throat cancer. About 455 participants will either have surgery or receive standard chemotherapy plus radiation, but the radiation dose may be lowered if the blood test shows a low risk of recurrence. The goal is to maintain high cure rates while reducing harsh side effects like trouble swallowing and dry mouth.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic in Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-••••
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Mayo Clinic in Florida
RECRUITINGJacksonville, Florida, 32224-9980, United States
Contact
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cisplatin chemotherapy and radiation therapy, guided by a blood test (NavDx) that detects HPV DNA
What this could lead to
If successful, this approach could allow doctors to safely lower radiation doses for many patients, reducing long-term side effects without raising the risk of cancer returning.
What could go wrong
This is a mid-stage trial with 455 participants, so results are not yet proven. The blood test may not accurately predict who needs less treatment, and some patients might still experience cancer recurrence or side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.