COLITIS, ULCERATIVE

This study tested a drug called vedolizumab as a long-term treatment for children and teenagers with moderate to severe ulcerative colitis, a painful bowel disease. The goal was to see if regular infusions of the drug could help patients achieve and maintain remission, meaning th…

This study tested whether a drug called spesolimab could help control moderate-to-severe ulcerative colitis in patients who hadn't responded well to other biologic treatments. About 98 adults received either the drug or a placebo for 12 weeks to see if it could reduce symptoms an…

This study tested an oral drug called MORF-057 in 39 adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The main goal was to see if the drug was safe, tolerable, and could reduce disease activity over 12 weeks of treatment. Participants who c…

This small study tested a new drug called BI 655130 in 8 people with active ulcerative colitis. The main goal was to understand how the drug works in the gut and to check if it was safe. Researchers measured changes in gut tissue and inflammation markers over 12 weeks of treatmen…

This study tested an investigational drug, TEV-48574, to see if it could help control two serious inflammatory bowel diseases: Crohn's disease and ulcerative colitis. For 14 weeks, 290 adults with moderate-to-severe disease received one of two doses or a placebo to see which was …

This study tested whether an experimental drug called JNJ-77242113 could help adults with moderate-to-severe ulcerative colitis who hadn't responded well to standard treatments. Researchers compared the drug against a placebo in 252 participants over 12 weeks to see if it reduced…

This study tested whether a daily oral medication called ozanimod could help control symptoms and induce remission in Japanese adults with moderate to severe ulcerative colitis. About 198 participants were randomly assigned to receive either the drug or a placebo pill for an init…

This study tested the safety and effectiveness of adding a new investigational drug, BI 655130, to standard therapy for adults with mild-to-moderate ulcerative colitis. The goal was to see if the add-on treatment could improve healing of the intestinal lining in patients whose di…

This study followed 79 adults with moderate to severe ulcerative colitis who had already participated in earlier trials of the drug spesolimab. Its main goal was to check the long-term safety of continuing this treatment. Researchers also looked at whether patients maintained sym…

This study monitored patients with ulcerative colitis or Crohn's disease in South Korea who were treated with vedolizumab (Kynteles injection) as part of their regular care. The main goals were to track side effects and see how many patients' symptoms improved while using this al…

This study observed how doctors in Switzerland treat adults with Crohn's disease or ulcerative colitis using the medicine vedolizumab. Researchers watched whether patients received the drug as an infusion into a vein or as an injection under the skin, and tracked how long they st…