New drug shows promise for Long-Term ulcerative colitis control

NCT ID NCT03648541

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 26 times

Summary

This study looked at the long-term safety of a drug called spesolimab in 79 adults with moderate to severe ulcerative colitis who had already taken part in earlier studies. The main goal was to track side effects over time, and researchers also checked how many patients achieved remission after about 6.5 years of treatment. The drug aims to control the disease rather than cure it, and patients may need ongoing medication.

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Contacts and locations

Locations

  • AKH - Medical University of Vienna

    Vienna, 1090, Austria

  • Asklepios Kliniken Westklinikum Hamburg

    Hamburg, 22559, Germany

  • Azienda Ospedaliera Universitaria di Padova

    Padova, 35128, Italy

  • Centre Hospitalier Universitaire de Liège

    Liège, 4000, Belgium

  • Columbia University Medical Center-New York Presbyterian Hospital

    New York, New York, 10032, United States

  • Digestive Disease Specialists Inc

    Oklahoma City, Oklahoma, 73112, United States

  • Doncaster Royal Infirmary

    Doncaster, DN2 5LT, United Kingdom

  • Emory University

    Atlanta, Georgia, 30322, United States

  • FSB Instit. HC Irkutsk Scient.Cent. Sibirian Branch of Russ. Acad. Scien.

    Irkutsk, 664033, Russia

  • Federal State Budgetary Institution " State Scientific Center of Coloproctology" MOH Russia

    Moscow, 123423, Russia

  • Guy's Hospital

    London, SE1 9RT, United Kingdom

  • Hospital Politècnic La Fe

    Valencia, 46026, Spain

  • Hospital Virgen del Rocío

    Seville, 41013, Spain

  • Hunter Holmes McGuire VA Medical Center

    Richmond, Virginia, 23249, United States

  • Hyogo College of Medicine Hospital

    Hyogo, Nishinomiya, 663-8501, Japan

  • Inje University Haeundae Paik Hospital

    Busan, 48108, South Korea

  • Istituto Clinico Humanitas

    Rozzano (MI), 20089, Italy

  • Klinikum Esslingen GmbH

    Esslingen am Neckar, 73730, Germany

  • Medical Research Center of Connecticut, LLC

    Hamden, Connecticut, 06518, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Military Medical Academy n.a. C. M. Kirov, St. Petersburg

    Saint Petersburg, 194044, Russia

  • National Medical Institute MSWiA

    Warsaw, 02-507, Poland

  • Ofuna Chuo Hospital

    Kanagawa, Kamakura, 247-0056, Japan

  • Ordensklinikum Linz GmbH - Barmherzige Schwestern

    Linz, 4010, Austria

  • Sapporo Higashi Tokushukai Hospital

    Hokkaido, Sapporo, 065-0033, Japan

  • Sapporo Tokushukai Hospital

    Hokkaido, Sapporo, 004-0041, Japan

  • Southern Star Research Institute, LLC

    San Antonio, Texas, 78229, United States

  • Texas Digestive Disease Consultants - Southlake

    Southlake, Texas, 76092, United States

  • Tokyo Medical and Dental University Hospital

    Tokyo, Bunkyo-ku, 113-8519, Japan

  • Tokyo Yamate Medical Center

    Tokyo, Shinjuku, 169-0073, Japan

  • UZ Leuven

    Leuven, 3000, Belgium

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Victoria Hospital (LHSC)

    London, Ontario, N6A 5W9, Canada

  • Whiston Hospital

    Prescot, L35 5DR, United Kingdom

  • Yeungnam University Medical Center

    Daegu, 42415, South Korea

Conditions

Explore the condition pages connected to this study.