New hope for kids with severe colitis: drug trial shows promise

NCT ID NCT04630028

First seen May 17, 2026 · Last updated May 17, 2026

Summary

This study tested a medicine called ustekinumab in 112 children with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. The goal was to see if the drug could help children reach remission (no symptoms) and to check its safety. Children first received the drug through an IV, then as shots under the skin. The study is now complete.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Birmingham Children's Hospital

    Birmingham, B4 6NH, United Kingdom

  • Borsod Abauj Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktato Korhaz

    Miskolc, 3526, Hungary

  • Cambridge University Hospitals NHS Foundation Trust

    Cambridge, CB2 0QQ, United Kingdom

  • Carmel Medical Center

    Haifa, 3436212, Israel

  • Charite-Universitätsmedizin Berlin - Berlin

    Berlin, 13353, Germany

  • Children's Center for Digestive Health Care

    Atlanta, Georgia, 30342, United States

  • Cliniques Universitaires Saint Luc

    Brussels, 1200, Belgium

  • Cook Childrens Medical Center

    Fort Worth, Texas, 76104, United States

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Dr. von Haunersches Kinderspital

    Munich, 80337, Germany

  • FSBI 'Scientific Centre of Children Health' of the Russian Academy of Medical Sciences

    Moscow, 119991, Russia

  • GASTROMED Sp. z o.o.

    Torun, 87 100, Poland

  • Gunma University Hospital

    Gunma, 371-0034, Japan

  • Instytut Pomnik Centrum Zdrowia Dziecka

    Warsaw, 04 730, Poland

  • Jichi Medical University Hospital

    Shimotsuke, 329-0498, Japan

  • Juntendo University Hospital

    Bunkyō City, 113 8431, Japan

  • KUNO Klinik St. Hedwig

    Regensburg, 93049, Germany

  • Kazan State Medical University

    Kazan', 420138, Russia

  • Kindai University Nara Hospital

    Ikoma, 630-0293, Japan

  • Korczowski Bartosz Gabinet Lekarski

    Rzeszów, 35-302, Poland

  • Kurume University Hospital

    Kurume, 830-0011, Japan

  • Levine Childrens at Atrium Health

    Charlotte, North Carolina, 28207, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Mie University Hospital

    Tsu, 514 8507, Japan

  • Miyagi Children's Hospital

    Sendai, 989-3126, Japan

  • Morristown Memorial Hospital

    Morristown, New Jersey, 07962, United States

  • National Center for Child Health and Development

    Setagaya Ku, 157 8535, Japan

  • Nemours DuPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Pediatric Specialists Of Virginia

    Fairfax, Virginia, 22031, United States

  • Penn State Hershey Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • Privolzhsky Research Medical University of Ministry of Health of Russian Federation

    Nizhny Novgorod, 603950, Russia

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Royal London Hospital

    London, E1 2AT, United Kingdom

  • Russian National Research Medical University named after N.I.Pirogov

    Moscow, 119571, Russia

  • Saitama Childrens Medical Center

    Saitama Shi, 330-8777, Japan

  • Saratov State Medical University

    Saratov, 410054, Russia

  • Schneider Children's Medical Center

    Petah Tikva, 4920235, Israel

  • Semmelweis Egyetem

    Budapest, 1083, Hungary

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Shamir Medical Center Assaf Harofeh

    Be’er Ya‘aqov, 70300, Israel

  • Sheba Medical Center

    Ramat Gan, 30700, Israel

  • Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz

    Nyíregyháza, 4400, Hungary

  • Szegedi Tudományegyetem, Gyermekgyógyászati Klinika és Gyermekegészségügyi Centrum

    Szeged, 6720, Hungary

  • Szpital im. M. Kopernika

    Gdansk, 80 803, Poland

  • UZ Brussel

    Jette, 1090, Belgium

  • UZ Gent

    Ghent, 9000, Belgium

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universitair Kinderziekenhuis Koningin Fabiola

    Brussels, 1020, Belgium

  • Universitatsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitatsklinikum Essen

    Essen, 45147, Germany

  • Universitatsklinikum Ulm

    Ulm, 89075, Germany

  • University Hospitals Bristol and Weston NHS Foundation Trust

    Bristol, BS2 8BJ, United Kingdom

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Universitätsklinikum Aachen

    Aachen, 52074, Germany

  • Uniwersytecki Szpital Dzieciecy w Krakowie

    Krakow, 30 663, Poland

  • WIP Warsaw IBD Point Profesor Kierkus

    Warsaw, 04 501, Poland

  • Yaroslavl Regional Children's Clinical Hospital

    Yaroslavl, 150032, Russia

Conditions

Explore the condition pages connected to this study.