New hope for ulcerative colitis: experimental drug JNJ-78934804 enters final testing phase

NCT ID NCT07577856

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This phase 3 trial tests whether the experimental drug JNJ-78934804 can help people with moderate to severe ulcerative colitis achieve remission better than the existing drug guselkumab. About 644 participants will receive either the new drug or guselkumab, and researchers will check at 48 weeks how many have no symptoms and healed gut lining. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-78934804 (an experimental drug) compared to guselkumab (TREMFYA)
What this could lead to: If successful, this could provide a new treatment option for people with moderate to severe ulcerative colitis, potentially helping more patients achieve remission.
What could go wrong: This is a phase 3 trial, but the experimental drug is still unproven. It may not work better than the existing drug guselkumab, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLITIS, ULCERATIVE

Contacts and locations

Locations

Antalya Training And Research Hospital
RECRUITING

Antalya, 07100, Turkey (Türkiye)
Assuta Medical center
RECRUITING

Ashdod, 7747629, Israel
BR Trials
RECRUITING

São Paulo, 01236 030, Brazil
Banksia Trials SA
RECRUITING

Adelaide, 5000, Australia
Barrie GI Associates
RECRUITING

Barrie, Ontario, L4M 7G1, Canada
Bezmialem University Medical Faculty
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Bnai Zion Medical Center
RECRUITING

Haifa, 60910, Israel
CHUM - Centre hospitalier universitaire de Montreal
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Charlton Digestive Disease Centre
RECRUITING

Hamilton, Ontario, L8N1Y2, Canada
Clinnova Research
RECRUITING

Anaheim, California, 92805, United States
Digestive Disease Specialists Inc
RECRUITING

Oklahoma City, Oklahoma, 73114, United States
GCP Clinical Research
RECRUITING

Tampa, Florida, 33609, United States
GI Research Institute (G.I.R.I.)
RECRUITING

Vancouver, British Columbia, V6Z 2K5, Canada
Galilee Medical Center
RECRUITING

Nahariya, 2210001, Israel
Gastro SB Clinic
RECRUITING

Chula Vista, California, 91910, United States
Great Lakes Gastroenterology Research, LLC
RECRUITING

Mentor, Ohio, 44060, United States
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
RECRUITING

Sapporo, 060-0033, Japan
Hospital Ampang
RECRUITING

Ampang, 68000, Malaysia
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 50586, Malaysia
Hospital Sultanah Nur Zahirah
RECRUITING

Kuala Terengganu, 20400, Malaysia
Istanbul University Cerrahpasa Medical Faculty
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Izmir Sehir Hastanesi
RECRUITING

Izmir, 35540, Turkey (Türkiye)
Kagoshima IBD Gastroenterology Clinic
RECRUITING

Kagoshima, 892-0843, Japan
Kitasato University Kitasato Institute Hospital
RECRUITING

Minatoku, 108-8642, Japan
Kocaeli University Medical Faculty
RECRUITING

Kocaeli, 41001, Turkey (Türkiye)
Kumamoto University Hospital
RECRUITING

Kumamoto, 860-8556, Japan
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 333, Taiwan
London Digestive Disease Institute
RECRUITING

London, Ontario, N6K 1M6, Canada
Mater Misericordiae Hospital
RECRUITING

South Brisbane, 4101, Australia
Matsuda Hospital
RECRUITING

Hamamatsu, 432-8061, Japan
Medical Associates Research Group, Inc.
RECRUITING

San Diego, California, 92123, United States
Meir Medical Center
RECRUITING

Kfar Saba, 4428164, Israel
Mersin University Medical Faculty
RECRUITING

Mersin, 33343, Turkey (Türkiye)
Michigan Center of Medical Research
RECRUITING

Farmington Hills, Michigan, 48334, United States
National Hospital Organization Mito Medical Center
RECRUITING

Higashi-Ibaraki, 311-3193, Japan
National Hospital Organization Osaka National Hospital
RECRUITING

Osaka, 540-0006, Japan
National Hospital Organization Shizuoka Medical Center
RECRUITING

Shimizu, 411-8611, Japan
New York Gastroenterology Associates
RECRUITING

New York, New York, 10075, United States
Oita Red Cross Hospital
RECRUITING

Ōita, 870-0033, Japan
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Pesquisare Saude
RECRUITING

Santo André, 09080-110, Brazil
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
SA Gastrointestinal Services
RECRUITING

Kurralta Park, 5037, Australia
Saga University Hospital
RECRUITING

Saga, 849-8501, Japan
Samsung Medical Center
RECRUITING

Gangnam Gu, 06351, South Korea
Sanchez Clinical Research, Inc
RECRUITING

Miami, Florida, 33157-6575, United States
Sanko Universitesi Hastanesi
RECRUITING

Gaziantep, 27090, Turkey (Türkiye)
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Sheba Medical Center
RECRUITING

Ramat Gan, 52621, Israel
South Edmonton Gastroenterology Research Clinic
RECRUITING

Edmonton, Alberta, Code: T6K 4B2, Canada
Southern Star Research Institute, LLC
RECRUITING

San Antonio, Texas, 78229, United States
Sultan Idris Shah Hospital
RECRUITING

Kajang, 43000, Malaysia
Takano Hospital
RECRUITING

Kumamoto, 862-0971, Japan
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 64239, Israel
The First Affiliated Hospital Sun Yat sen University
RECRUITING

Guangzhou, 510080, China
Tokyo Metropolitan Bokutoh Hospital
RECRUITING

Sumida Ku, 130 8575, Japan
Toronto Immune and Digestive Health Institute Inc
RECRUITING

Toronto, Ontario, M6A 3B4, Canada
Tri-State Gastroenterology Assoc
RECRUITING

Crestview Hills, Kentucky, 41017, United States
Tsujinaka Hospital Kashiwanoha
RECRUITING

Kashiwa, 277-0871, Japan
Viable Clinical Research
RECRUITING

Kentville, Nova Scotia, B4N 0A3, Canada
Wolfson Medical Center
RECRUITING

Holon, 5822012, Israel
Yamanashi Prefectural Central Hospital
RECRUITING

Yamanashi, 400-8506, Japan

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