INFLAMMATORY BOWEL DISEASES

This study is testing whether pentoxifylline, an existing medication, can help control ulcerative colitis symptoms. Researchers will enroll 60 adults with mild to moderate ulcerative colitis to assess safety and effectiveness. The trial will measure changes in bowel symptoms, ble…

This Canadian study is testing whether transferring healthy gut bacteria from donor stool (fecal transplant) can help control ulcerative colitis. Researchers will compare the transplant to a placebo in 85 adults with active disease to see if a larger trial is worthwhile. The goal…

This study is testing if a common sweetener called xylitol, taken as a daily capsule, can safely remove C. difficile bacteria from the gut of people with inflammatory bowel disease (IBD). The goal is to prevent these patients from developing a serious C. difficile infection. Abou…

This study aims to find out which newer medications work best and are safest for children with inflammatory bowel disease (IBD) when standard anti-TNF drugs have stopped working. It will follow about 1100 children and teens who are already starting one of these newer medications …

This study is testing a medical device that filters harmful substances from the blood to help calm severe flare-ups of Crohn's disease and ulcerative colitis. It will compare patients receiving standard therapy alone to those receiving standard therapy plus the blood-filtering tr…

This study is testing whether the antidepressant medication duloxetine can help reduce psychological distress and improve daily functioning in adults with inflammatory bowel disease (IBD). Thirty-two participants with elevated anxiety, depression, or IBD-related disability will t…

This study is testing a brief, one-day therapy workshop designed to help Veterans who have both inflammatory bowel disease (like Crohn's or colitis) and a mental health condition like depression or anxiety. The workshop uses acceptance and commitment therapy (ACT) to teach coping…

This study is testing whether a special dietary supplement called GenesiDol can help reduce joint and muscle pain in people with inflammatory bowel disease (IBD). It will involve 40 adults with IBD who experience persistent musculoskeletal pain. Researchers will measure changes i…

This study is testing a new self-management program designed to help people with active Crohn's disease or ulcerative colitis. Researchers want to see if teaching patients specific skills and behaviors can improve their quality of life and health outcomes. The main goal of this s…

This study is testing whether a brain training technique called neurofeedback can help manage chronic pain in people with inflammatory bowel disease (IBD). Researchers will enroll 80 adults with IBD and persistent musculoskeletal pain. Half will receive eight sessions of neurofee…

This study aims to understand the connection between vitamin D deficiency and symptom flare-ups in people with Crohn's disease or ulcerative colitis. Researchers will measure vitamin D levels in the blood of 100 adults with active inflammatory bowel disease (IBD). The goal is to …

This study aims to see if measurements of blood platelets, which are easy to get from a standard blood test, can help doctors understand how active a patient's inflammatory bowel disease (IBD) is. Researchers will enroll 84 adults with Crohn's disease or ulcerative colitis to che…

This study aims to understand if anxiety, depression, or stress make advanced treatments for inflammatory bowel disease (IBD) wear off faster. Researchers will ask 450 people with IBD who are receiving specific infusion medications to complete mental health questionnaires and tra…

This study aims to learn if areas of bowel inflammation in people with Crohn's disease or ulcerative colitis are warmer than healthy tissue. During a standard colonoscopy, researchers will use a special temperature probe to measure heat inside the colon. The goal is to gather inf…

This study aims to see if having anemia (low red blood cells) can help predict how severe inflammatory bowel disease (IBD) will be and how often patients might need to go to the hospital. Researchers will follow 83 adult patients with IBD at an Egyptian hospital to see if their a…

This study aims to see if a special type of heart ultrasound, called speckle tracking echocardiography, can detect very early heart changes in people with inflammatory bowel disease (IBD) before any symptoms appear. Researchers will enroll 100 adults with IBD to compare this adva…