INFLAMMATORY BOWEL DISEASES

This study tested an oral drug called MORF-057 in 39 adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The main goal was to see if the drug was safe, tolerable, and could reduce disease activity over 12 weeks of treatment. Participants who c…

This study investigated whether the background of a fecal transplant donor affects treatment success for ulcerative colitis, a chronic gut disease. Researchers compared transplants from donors of Han and Bai ethnicities to see if one led to better control of the disease. The goal…

This study tested whether adding a common cholesterol-lowering drug (atorvastatin) to standard mesalamine treatment could better control ulcerative colitis. It involved 54 adults with mild-to-moderate disease who were not on strong immunosuppressants. Researchers measured if the …

This study tested if adding a drug called bezlotoxumab to a fecal microbiota transplant (FMT) works better than FMT alone to prevent C. difficile infection (CDI) from coming back. It involved 61 adults with inflammatory bowel disease (IBD) who kept getting repeat CDI. Participant…

This study tested whether using a blood test to identify newly diagnosed inflammatory bowel disease (IBD) patients at high risk for severe disease could improve their outcomes. 300 patients were randomly assigned to either have their treatment guided by this blood test result or …

This study monitored patients with ulcerative colitis or Crohn's disease in South Korea who were treated with vedolizumab (Kynteles injection) as part of their regular care. The main goals were to track side effects and see how many patients' symptoms improved while using this al…

This study tested whether adding the antibiotic minocycline to the standard medication mesalamine helps people with mild-to-moderate ulcerative colitis. It involved 46 adults to see if the combination better controls bowel inflammation and symptoms. The goal was to find a safe, l…

This study tested a safer way to give IV nutrition to patients recovering from colon surgery. Researchers wanted to see if giving nutrition through a regular arm IV (instead of a deep chest line) could help patients heal better and avoid complications. They enrolled 200 patients …

This study compared two standard colonoscopy techniques used to screen for early colon cancer in people who have had inflammatory bowel disease (IBD) for over eight years. Researchers wanted to see if a newer high-definition camera method was as good as an older dye-spraying meth…

This study aimed to find better blood tests to diagnose inflammatory bowel diseases (IBD), like Crohn's disease and ulcerative colitis. Researchers measured four specific proteins in the blood of 70 newly diagnosed, untreated patients. The goal was to see if these proteins could …

This study tested whether following a specific 'Tasty & Healthy' diet for 8 weeks could lower biological markers associated with the future risk of developing Crohn's disease. It involved 29 healthy people who were close relatives of someone with Crohn's and had elevated risk mar…

This study tested a new coaching program to help teenagers with juvenile arthritis or inflammatory bowel disease (IBD) move from pediatric to adult healthcare. 27 teens were randomly assigned to receive either the coaching sessions or standard care. The main goal was to see if th…

This small, exploratory study tested a single session using a virtual reality app with an AI-powered guide to provide mental health support. It involved 22 adults with inflammatory bowel disease (IBD) who also had mild to moderate anxiety or depression. The main goal was to see i…

This study tested whether a special plant-based, low-calorie 'fasting mimicking' diet could help reduce depression symptoms in people with Crohn's disease or ulcerative colitis (IBD). 42 adult participants with mild-to-moderate depression tried three cycles of the 5-day diet. Res…

This study tested if adding an anti-nausea medicine (ondansetron) to the standard laxative drink could make the colonoscopy preparation process easier for children and teens. The goal was to see if reducing nausea and discomfort helped patients finish the prep drink, leading to a…

This study tested a new self-management program designed to help people with Crohn's disease or ulcerative colitis. The program taught 55 participants strategies for tracking symptoms, managing stress and pain, improving sleep, and adjusting diet. Researchers wanted to see if the…

This study tested whether eating a gluten-free diet could reduce gut symptoms and fatigue in people with ulcerative colitis. Fifteen participants tried one week of a high-gluten diet and one week of a gluten-free diet in a random order. Researchers measured their symptoms and col…

This study aimed to understand why inflammatory bowel diseases (IBD) like Crohn's and colitis are often more severe in children. Researchers tested the idea that DNA leaking from cells might trigger and worsen gut inflammation through a specific biological pathway. They analyzed …

This study aimed to create a new lab tool for developing future treatments. Researchers took tiny tissue samples from patients with inflammatory bowel disease (IBD) and healthy people during routine colonoscopies. They grew these samples into 3D 'mini-guts' (organoids) in the lab…

This study observed how doctors in Switzerland treat adults with Crohn's disease or ulcerative colitis using the medicine vedolizumab. Researchers watched whether patients received the drug as an infusion into a vein or as an injection under the skin, and tracked how long they st…

This study aimed to understand how oral health issues like gum disease, cavities, and tooth loss affect the daily life and well-being of people with Crohn's disease or ulcerative colitis. Researchers compared survey responses from 138 adults with IBD to people without IBD. The go…

This study looked at the safety of anti-TNF medications for pregnant women with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers analyzed French national health data from over 8,700 pregnancies to understand whether these medications help…

This study aimed to understand how gut bacteria are different in people with Inflammatory Bowel Disease (IBD) or Parkinson's Disease. Researchers compared stool and blood samples from 15 patients to see if specific bacteria could be linked to these conditions. The goal was to fin…

This study aimed to better understand how the gut repairs itself in people with inflammatory bowel disease (like Crohn's or colitis) and a condition called familial polyposis. Researchers grew tiny 3D models of the gut, called organoids, from small tissue samples taken during rou…