INFLAMMATORY BOWEL DISEASES

This study tested whether adding a drug called bezlotoxumab to a fecal transplant (FMT) could better prevent repeat C. diff infections in people with inflammatory bowel disease (IBD). About 61 adults with both IBD and recurrent C. diff were randomly assigned to get FMT plus bezlo…

This study looked at whether adding atorvastatin, a common cholesterol medicine, to standard ulcerative colitis treatment can improve quality of life. 54 adults with mild to moderate ulcerative colitis took part. The goal was to see if the drug's anti-inflammatory effects could h…

This study tested whether transplanting healthy donor stool into the gut could help people with ulcerative colitis (UC), a chronic inflammatory bowel disease. 102 participants with mild-to-moderate UC received fecal microbiota transplantation (FMT) from different donors. The goal…

This study looked at whether adding the antibiotic minocycline to standard mesalamine therapy can better control ulcerative colitis, a chronic inflammatory bowel disease. Forty-six adults with mild to moderate UC took part. The main goal was to measure changes in disease activity…

This study looked at 688 people with ulcerative colitis or Crohn's disease who received Vedolizumab (Kynteles) as part of their normal care in South Korea. The main goal was to track side effects and see how many patients felt better after treatment. Vedolizumab helps control inf…

This study tested an experimental drug called MORF-057 in 39 adults with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. The goal was to see if the drug could reduce gut inflammation and improve symptoms over 12 weeks. Participants took the pill by mo…

This study tested a new approach for people newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers used a blood test that measures proteins to identify patients at high risk for a worse disease course. These high-risk …

This study looked at whether giving nutrition through a small vein in the arm (peripheral parenteral nutrition) helps patients recover better after colorectal surgery. The trial included 200 adults who had surgery for conditions like colorectal cancer or inflammatory bowel diseas…

This study looked at whether certain proteins in the blood can help diagnose inflammatory bowel disease (IBD) more accurately without needing invasive procedures. Researchers measured levels of four markers in 70 newly diagnosed patients before and after treatment. The goal is to…

This study tested whether a special diet called Tasty & Healthy could lower the risk of developing Crohn's disease in 29 healthy people who have a close family member with the condition. Participants followed the diet for 8 weeks, and researchers measured gut inflammation and oth…

This study tested whether ondansetron, a common anti-nausea medication, helps children aged 2 to 20 better tolerate the bowel preparation needed before a colonoscopy. The goal was to see if it improves bowel cleanliness and reduces discomfort like pain, bloating, nausea, and vomi…

This study looked at whether a short-term, plant-based low-calorie diet (called a fasting mimicking diet) could improve depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild to moderate depression and IBD completed three 5-day diet cycles. Resea…

This small study tested whether a digital wellness app using artificial intelligence and virtual reality could safely provide mental health support to adults with inflammatory bowel disease who also have mild anxiety or depression. Twenty-two participants used the app during a si…

This study tested a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Researchers wanted to …

This study looked at whether eating gluten-free can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults each spent one week on a gluten-free diet plus a special granola bar, and another week on the same diet but with a high-gluten bar. They rep…

This study looked at the use of antiTNFα drugs in pregnant women with inflammatory bowel disease (IBD) to see if doctors followed guidelines and what the risks and benefits were for both mother and baby. Researchers analyzed data from over 8,700 pregnancies in France between 2011…

This study took small tissue samples from 16 people with or without inflammatory bowel disease (IBD) during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how these organoids respond to radiation and potential …

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (IBD) to understand how DNA that escapes from cells might worsen inflammation. Researchers analyzed blood, stool, and gut tissue samples to study a specific pathway called cGAS-STING. The goal was to id…

This study looked at physical fitness in 100 children aged 10-17 with chronic inflammatory bowel disease (like Crohn's or ulcerative colitis) and compared them to healthy children of the same age, size, and sex. Researchers measured things like heart-lung fitness, muscle strength…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds early signs of colon cancer better: high-definition white light or dye-spraying chromo-colonoscopy. Participants had IBD for at least eight years. The goal wa…

This study aimed to create a tool to help nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). Researchers worked with 792 participants, including men with IBD and healthcare professionals, to understand current gaps in care. The…

This study looked at how menstrual cycles and hormonal birth control affect symptoms like belly pain and diarrhea in women with inflammatory bowel disease (IBD). Researchers surveyed 50 women to understand their preferences and willingness to join future trials. The goal is to de…

This study tested whether a transition coach could help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult healthcare. 27 teens took part in a coaching program to build self-management skills. The main goal was to see if …

This study took small tissue samples from the intestines of 110 people with inflammatory bowel disease (Crohn's or ulcerative colitis), familial adenomatous polyposis, or healthy controls. Researchers grew these samples into mini-organs called organoids to study how intestinal st…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study looked at the gut bacteria of 15 people with inflammatory bowel disease (IBD) or Parkinson's disease and compared them to healthy individuals. Researchers collected stool and blood samples to see which bacteria were present and whether bacteria were leaking from the gu…

This study observed 92 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) in Switzerland who were taking vedolizumab either as an IV infusion or a shot under the skin. Researchers tracked which route patients chose and why, and how long they stayed on treatmen…

This early-stage study tested a new oral drug, IPG11406, in 66 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. The goal was not to treat any disease, but to gather important safety and dosing information for f…