Gut bacteria may hold key to treating severe colitis

NCT ID NCT04272307

Completed Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three months. The goal is to find biological markers that could help doctors choose the most effective medical therapy and avoid the need for colon removal surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could identify biomarkers to guide personalized treatment for severe ulcerative colitis, potentially reducing the need for surgery.
What could go wrong: This is a small early-phase pilot study, so findings may not be definitive or generalizable. The research is observational and does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colitis inflammatory bowel disease ulcer disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLITIS INFLAMMATORY BOWEL DISEASES ULCERATIVE

Contacts and locations

Locations

Centre Hospitalier Universitaire de Bordeaux

Bordeaux, 33076, France

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