INFLAMMATORY BOWEL DISEASES

This study tests three different doses of an experimental drug called MORF-057 against a placebo in 280 adults with moderate to severe ulcerative colitis. The goal is to see if the drug can safely reduce symptoms and help patients achieve remission. Participants must have had act…

This study aimed to test whether stem cells from bone marrow could safely help people with a severe form of pouchitis, a complication after colon surgery for inflammatory bowel disease. The trial was withdrawn before enrolling any participants, so no results are available. The ap…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. About 45 kids aged 8 to 16 who are already on anti-TNF medication will take the supplement for up to 48 weeks. The goal is to see if this…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. 123 adults starting a new oral or injectable treatment will use the system or standard care for 12 months. The goal is to see…

This study tests whether a plant-based resistant starch, tailored to each child's gut, can help restore a healthier gut microbiome in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for several months while researchers measur…

This study tests whether using a computer dashboard (iDose) to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the dashboard approach h…

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 children with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to increase butyrate produc…

This study tests whether a virtual reality (VR) program can help manage pain in people with inflammatory bowel disease (IBD). About 40 adults with IBD and abdominal pain will use a VR headset at home for 4 weeks. The goal is to see if the program is easy to use and helps reduce p…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get the program (which includes a navigator, skills training, and education) or standard care. The goal is t…

This study follows 15,000 adults and children (age 2+) with Crohn's disease, ulcerative colitis, or indeterminate colitis for up to 5 years. Researchers will collect data on how patients respond to treatments, side effects, and disease changes in everyday medical practice. The go…

This study checks if a thin tube placed through the nose can measure how leaky the gut is in healthy adults. Researchers will test if the device gives accurate readings and clear images. The goal is to see if this tool could help diagnose gut problems in the future.

This study is collecting blood and tissue samples from 1,000 people with inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), or functional gut disorders, as well as those receiving cell therapies like CAR-T. Researchers will analyze the immune system in detail to …

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD) to learn more about the condition. Researchers hope this information will lead to better treatments and outcomes. Participants must be between 18 and 85 years old and …

This study is a large registry that follows over 2,200 adults with inflammatory bowel disease (IBD) across North America. It does not test new treatments but instead observes how approved therapies work in everyday practice, including their effectiveness, safety, and how the dise…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study looks at how computer programs can help doctors assess inflammatory bowel disease (IBD) more accurately. Researchers will analyze videos, tissue samples, and scans from 200 patients to create digital tools that may improve diagnosis and monitoring. The goal is to devel…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study is testing a special temperature probe that can be used during a routine colonoscopy to measure heat in the lining of the colon. The goal is to see if this tool can help detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and …

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…