Could a common antidepressant calm Crohn's belly pain even when inflammation is gone?
NCT ID NCT07556718
First seen Apr 30, 2026 · Last updated May 13, 2026 · Updated 3 times
Summary
Many people with Crohn's disease still have stomach pain, bloating, or diarrhea even when their disease is not active. This study tests if a low dose of amitriptyline, a drug already used for irritable bowel syndrome, can safely reduce those symptoms. About 100 adults with quiet Crohn's disease will receive either amitriptyline or a placebo for several weeks, and researchers will track side effects and symptom improvement.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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