New hope for kids with Crohn's: drug trial targets remission

NCT ID NCT07298421

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This phase 3 trial tests a drug called afimkibart in 100 children aged 2-17 with moderate-to-severe Crohn's disease. The goal is to see if it can help children feel better and heal their intestines. Participants will receive the drug as an IV infusion or injection, and researchers will monitor safety and effectiveness over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: afimkibart (a drug given by IV infusion or injection)
What this could lead to: If it works, this could provide a new treatment option to help children with Crohn's disease achieve remission and heal their gut lining.
What could go wrong: This is still an experimental drug; it may not work better than existing treatments, and side effects are possible. The trial is relatively small (100 children), so results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATELY TO SEVERELY ACTIVE CROHNS DISEASE

Contacts and locations

Locations

CECIP - Centro de Estudos Clínicos do Interior Paulista
RECRUITING

Jaú, São Paulo, 17201-130, Brazil
Chulalongkorn University
RECRUITING

Bangkok, 10330, Thailand
FAICIC Clinical Research
RECRUITING

Veracruz, 91900, Mexico
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Perth Children's Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Ramathibodi Hospital
RECRUITING

Bangkok, Thailand
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Sheffield Childrens Hospital
RECRUITING

Sheffield, S10 2TH, United Kingdom
Siriraj Hospital
RECRUITING

Bangkok, 10700, Thailand

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