New hope for Crohn's sufferers: phase 3 drug trial launches

NCT ID NCT06819891

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This study tests a new drug called RO7790121 (Afimkibart) in people with moderate-to-severe Crohn's disease. The goal is to see if the drug can reduce symptoms and heal the gut lining better than a placebo. About 425 adults who have not responded well to other treatments will take part. The study is double-blind, meaning neither participants nor doctors know who gets the real drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATELY TO SEVERELY ACTIVE CROHNS DISEASE

Contacts and locations

Locations

ABAWI spol. s r.o.
RECRUITING

Bratislava, 821 07, Slovakia
AIG Hospitals
RECRUITING

Gachibowli, Telangana, 500032, India
Advanced Medical Research Center
RECRUITING

Port Orange, Florida, 32127, United States
Affiliated Hospital of Jiangsu University
RECRUITING

Zhenjiang, 212001, China
All India Institute Of Medical Sciences (AIIMS)
RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
Allied Biomedical Research Institute, Inc
RECRUITING

Miami, Florida, 33155, United States
Amicare Sp. z o.o. S.K.
RECRUITING

Lodz, 91-495, Poland
Amicis Research Center
RECRUITING

Santa Clarita, California, 91355, United States
Amrita Institute of Medical Sciences
RECRUITING

Kochi, Kerala, 682041, India
Asst Degli Spedali Civili Di Brescia
RECRUITING

Brescia, Lombardy, 25123, Italy
Auzmer Research
RECRUITING

Lakeland, Florida, 33813, United States
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Barrie GI Associates
RECRUITING

Barrie, Ontario, L4M 7G1, Canada
Baton Rouge General Medical Center
RECRUITING

Baton Rouge, Louisiana, 70809, United States
Beijing Union Hospital
RECRUITING

Beijing, 100730, China
Borzan Polyclinic
RECRUITING

Osijek, 31000, Croatia
Bronglais General Hospital
RECRUITING

Llanrhystud, SY23 1ER, United Kingdom
CECIP - Centro de Estudos Clínicos do Interior Paulista
RECRUITING

Jaú, São Paulo, 17210-190, Brazil
CH Dptal Les Oudairies
RECRUITING

La Roche-sur-Yon, 85925, France
CHRU de Lille - Hopital Claude Huriez
RECRUITING

Lille, 59037, France
CHU Clermont Ferrand - Hôpital d'Estaing
RECRUITING

Clermont-Ferrand, 63000, France
CHU St Pierre (St Pierre)
RECRUITING

Brussels, 1000, Belgium
CHU Tours - Hôpital Trousseau
RECRUITING

Chambray-lès-Tours, 37170, France
CICE 9 de Julio
RECRUITING

San Miguel de Tucumán, T4000DPK, Argentina
CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Carta - Clinical Associates In Research Therapeutics Of America;LLC
RECRUITING

San Antonio, Texas, 78212, United States
Centre hospitalier Lyon Sud
ACTIVE_NOT_RECRUITING

Pierre-Bénite, Rhône, 69310, France
Centro Hospitalar de Entre Douro e Vouga - H. São Sebastião
RECRUITING

Santa Maria da Feira, 4520-211, Portugal
Centro de Investigación Clínica UC-CICUC
RECRUITING

Santiago, 8330034, Chile
Centrum Medyczne Promed
RECRUITING

Krakow, 31-513, Poland
Centrum Zdrowia-MDM
RECRUITING

Warsaw, 00-189, Poland
Charlotte Gastroenterology and Hepatology, P.L.L.C
RECRUITING

Charlotte, North Carolina, 28207, United States
Chevy Chase Clinical Research
RECRUITING

Chevy Chase, Maryland, 20815, United States
Chosun University Hospital
RECRUITING

Gwangju, 61453, South Korea
Cleveland Clinic Florida
RECRUITING

Weston, Florida, 33331, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Colsanitas S.A. - Sede Clinica Reina Sofia
RECRUITING

Bogotá, 111071, Colombia
Clinical Applications Laboratories, Inc.
RECRUITING

San Diego, California, 92103, United States
Clinical Hospital Centre Zagreb
RECRUITING

Zagreb, 10000, Croatia
Clinical Inquest Center
RECRUITING

Beavercreek, Ohio, 45431, United States
Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka Komandytowa
RECRUITING

Poznan, 61-731, Poland
Cliniques Universitaires St-Luc
RECRUITING

Brussels, 1200, Belgium
Clínica de la Mujer
RECRUITING

Bogotá, 110221, Colombia
Coral Sea Clinical Research Institute
WITHDRAWN

Mackay, Queensland, 4740, Australia
Dartmouth-Hitchcock Medical Center-Norris Cotton Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Digestive Disease Medicine of Central New York
RECRUITING

Utica, New York, 13502, United States
Digestive Health Specialists of the Southeast
RECRUITING

Dothan, Alabama, 36305, United States
Digestive and Liver Center of Florida
RECRUITING

Orlando, Florida, 32825, United States
EMC Instytut Medyczny SA
RECRUITING

Późna, 60-309, Poland
Ellipsis Research Group
RECRUITING

Brooklyn, New York, 11215, United States
Eminat Research Group
RECRUITING

Miramar, Florida, 33027, United States
Empire Clinical Research
WITHDRAWN

Pomona, California, 91767, United States
Endomedix Kft.
RECRUITING

Budapest, 1139, Hungary
Endoskopia Sp. z o.o.
RECRUITING

Sopot, 81-756, Poland
Fairfield General Hospital
RECRUITING

Bury, BL9 7TD, United Kingdom
Fakultni nemocnice Ostrava
RECRUITING

Ostrava - Poruba, 708 52, Czechia
First Affiliated Hospital of Gannan Medical University
RECRUITING

Ganzhou, Jiangxi, 341000, China
Footscray Hospital
RECRUITING

Footscray, Victoria, 3011, Australia
Fundacion Hospital de Alcorcon
RECRUITING

Alcorcón, Madrid, 28922, Spain
GI Alliance
RECRUITING

Garland, Texas, 75044, United States
GI Alliance - Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
GI Alliance-Richmond
RECRUITING

Richmond, Virginia, 23229, United States
GNRR Digestive Clinics and Research Center Inc.
RECRUITING

Brampton, Ontario, L6S 0E2, Canada
Gabinety Lekarskie Rivermed
RECRUITING

Późna, 61-441, Poland
Galenus Group Inc
RECRUITING

Lehigh Acres, Florida, 33936, United States
Gandhi Hospital
RECRUITING

Secunderabad, Telangana, 500003, India
Gastro One
RECRUITING

Cordova, Tennessee, 38018, United States
Gastroenterology Associates of Western Michigan, P.L.C.
RECRUITING

Wyoming, Michigan, 49519, United States
Gastrointestinal Associates Research
RECRUITING

Flowood, Mississippi, 39232, United States
Gastromed Kralisz, Romatowski, Stachurska sp.j.
RECRUITING

Bia?ystok, 15-322, Poland
Geomedical Orvosi Kft
RECRUITING

Budapest, 1066, Hungary
Guangzhou First People's Hospital
RECRUITING

Guangzhou, 510180, China
Gujarat Gastro and Vascular Hospital
RECRUITING

Surat, Gujarat, 395009, India
Hadassah Medical Center
RECRUITING

Jerusalem, 9112001, Israel
Hainan General Hospital
RECRUITING

Haikou, 570311, China
Hanyang University Seoul Hospital
RECRUITING

Seoul, 04763, South Korea
Hebei Medical University - The Second Hospital
RECRUITING

Shijiazhuang, 050004, China
Hepato-Gastroenterologie HK, s.r.o.
RECRUITING

Hradec Králové, 500 12, Czechia
Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education
RECRUITING

Newport Beach, California, 92663, United States
Homestead Associates in Research, Inc.
RECRUITING

Miami, Florida, 33033, United States
Hopital Dupuytren
RECRUITING

Limoges, 87042, France
Hopital Saint-Eloi
RECRUITING

Montpellier, 34295, France
Hospital Clinico Univ. Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital General Universitario Gregorio Maranon
RECRUITING

Madrid, 28040, Spain
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-000, Brazil
Hospital Sao Teotonio
RECRUITING

Viseu, 3504-509, Portugal
Hospital Sírio-Libanês
RECRUITING

São Paulo, São Paulo, 01308-050, Brazil
Hospital Universitario Puerta de Hierro
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario San Ignacio
RECRUITING

Bogotá, 000472, Colombia
Hospital de Base de Sao Jose do Rio Preto
RECRUITING

São José do Rio Preto, São Paulo, 15090-000, Brazil
Hospital de Braga
RECRUITING

Braga, 4710-243, Portugal
Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Hospital de Sao Joao
RECRUITING

Porto, 4202-451, Portugal
Huizhou First Hospital
RECRUITING

Huizhou, China
Hôpital Henri Mondor
RECRUITING

Créteil, 94000, France
Hôpital Saint-Louis
RECRUITING

Paris, 75475, France
Hôpital de Brabois Adultes
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
I.R.C.C.S Policlinico San Donato
RECRUITING

San Donato Milanese (MI), Lombardy, 20097, Italy
IRCCS Ospedale Sacro Cuore Don Calabria
RECRUITING

Negrar, Veneto, 37024, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
ISCARE a.s.
RECRUITING

Prague, 170 04, Czechia
Institut des MICI, Clinique Ambroise Paré
ACTIVE_NOT_RECRUITING

Neuilly-sur-Seine, 92200, France
Institute of Post Graduate Medical Education and Research (IPGMER) and SSKM Hospital
RECRUITING

Kolkata, West Bengal, 700020, India
Instituto Lobus Unimed Volta Redonda
RECRUITING

Volta Redonda, Rio de Janeiro, 27258-000, Brazil
Instituto Medico CER
RECRUITING

Quilmes, B1878DVB, Argentina
Institutu Klinicke a Experimentaini Mediciny (IKEM);Klinika hepatogastroenterologie
RECRUITING

Prague, 140 21, Czechia
Integrity Advanced Therapeutics PLLC
RECRUITING

Houston, Texas, 77090, United States
Intercity Gastroenterology
RECRUITING

Fresh Meadows, New York, 11366, United States
J&A Clinical Research
RECRUITING

Doral, Florida, 33126, United States
James J Peters Veterans Affairs Medical Center
RECRUITING

The Bronx, New York, 10468, United States
Jinhua municipal central hospital
RECRUITING

Jinhua, Zhejiang, 321013, China
KM Management spol. s r.o.
RECRUITING

Nitra, 949 01, Slovakia
Klinikum Ernst von Bergmann
RECRUITING

Potsdam, 14467, Germany
Klinikum Wels-Grieskirchen
RECRUITING

Wels, 4600, Austria
Korea University Ansan Hospital
RECRUITING

Ansan-si, Gyeonggi-do, 15355, South Korea
Krajska zdravotni, a.s. ? Masarykova nemocnice v Usti nad Labem, o.z., Ocni oddeleni
RECRUITING

Ústí nad Labem, 401 13, Czechia
Kurnool Medical College
RECRUITING

Kurnool, Andhra Pradesh, 518002, India
LDDI Clinical Trials Inc.
RECRUITING

London, Ontario, N6K 1M6, Canada
London Health Sciences Centre Uni Campus
WITHDRAWN

London, Ontario, N6A 5A5, Canada
Louisiana Research Center - GastroIntestinal Associates
RECRUITING

Shreveport, Louisiana, 71105, United States
MC " Sveti Ivan Rilski Chudotvorets- 2010
RECRUITING

Plovdiv, 4003, Bulgaria
MIDAS Multispeciality Hospital
RECRUITING

Nagpur (urban), Maharashtra, 440018, India
MZ Badania Slowik Zymla Sp.j.
RECRUITING

Knurów, 44-190, Poland
Macquarie University Hospital
RECRUITING

Macquarie Park, New South Wales, 2109, Australia
Medical Center Kermed
RECRUITING

Bydgoszcz, 85-231, Poland
Medicina de Precisión - Celerity
RECRUITING

Las Condes, 7560908, Chile
Medon Clinical Research sp. z o.o
RECRUITING

Warsaw, 02-679, Poland
Medrise sp z o.o
RECRUITING

Lublin, 20-582, Poland
Mercy Medical Center
RECRUITING

Baltimore, Maryland, 21202, United States
Miami Beach Clinical Research Center
RECRUITING

Miami Beach, Florida, 33141, United States
Morehouse School Of Medicine
RECRUITING

Atlanta, Georgia, 30310-1495, United States
Multiprofile Hospital for Active Treatment Uni Hospital;Department of Gastroenterology.
RECRUITING

Panagyurishte, 4500, Bulgaria
Newdata Clinical Trials
RECRUITING

Aracaju, Sergipe, 49055-000, Brazil
Om Research LLC
RECRUITING

Lancaster, California, 93534, United States
Oncomedica S.A.
RECRUITING

Montería, 230002, Colombia
One GI: GHP - Gastroenterology Health Partners Louisville
RECRUITING

Louisville, Kentucky, 40218, United States
Ordensklinikum Linz Barmherzige Schwestern
RECRUITING

Linz, 4010, Austria
Ospedale Madonna delle Grazie
RECRUITING

Matera, Basilicate, 75100, Italy
Osrodek Badan Klinicznych Bd Research
RECRUITING

I?awa, 14-200, Poland
Peak Gastroenterology Associates
RECRUITING

Colorado Springs, Colorado, 80907, United States
Peters Medical Research (PMR), LLC
RECRUITING

High Point, North Carolina, 27260, United States
PlanetMed sp. z o.o.
RECRUITING

Wroc?aw, 52-210, Poland
Policlinico Universitario Agostino Gemelli
RECRUITING

Rome, Lazio, 00168, Italy
Policlinico Universitario Campus Biomedico Di Roma
RECRUITING

Rome, Lazio, 00128, Italy
Rejuvaline Medical Research
RECRUITING

Miami, Florida, 33155, United States
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, 200127, China
Robert Wood Johnson University Hospital
RECRUITING

New Brunswick, New Jersey, 08901, United States
Robley Rex VA Medical Center
RECRUITING

Louisville, Kentucky, 40206, United States
Royal London Hospital
RECRUITING

London, E1 1FR, United Kingdom
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
SMS Superspeciality Hospital
RECRUITING

Jaipur, Rajasthan, 302007, India
SR Kalla Memorial Gastro & General Hospital
RECRUITING

Jaipur, Rajasthan, 302006, India
Santos Research Center, CORP
RECRUITING

Tampa, Florida, 33615, United States
Semmelweis Egyetem
RECRUITING

Budapest, 1082, Hungary
Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, 110004, China
Shree Giriraj Multispeciality Hospital
RECRUITING

Rajkot, Gujarat, 360005, India
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
Sonomed Sp. z o.o.
RECRUITING

Szczecin, 71-685, Poland
Southmead Hospital
RECRUITING

Bristol, BS10 5NB, United Kingdom
Specialists in Gastroenterology
RECRUITING

St Louis, Missouri, 63141, United States
Spital Digenio - Centrul de Excelen?? în Afec?iuni Digestive
RECRUITING

Cluj-Napoca, DUMMY_VALUE, Romania
Stanford Medicine Outpatient Center
RECRUITING

Redwood City, California, 94063, United States
Stepping Hill Hospital
ACTIVE_NOT_RECRUITING

Stockport, SK2 7JE, United Kingdom
Sun City Clinical Research
RECRUITING

Glendale, Arizona, 85304, United States
Surat Institute of Digestive Sciences Hospitals
RECRUITING

Surat, Gujarat, 395002, India
Szpital Miejski sw. Jana Paw?a II w Elblagu
RECRUITING

Elblag, 82-300, Poland
TDDC GI Alliance research Webster
RECRUITING

Webster, Texas, 77598, United States
Texas Digestive Disease Consultants-Lubbock powered by GI Alliance
RECRUITING

Lubbock, Texas, 79410, United States
The Catholic University of Korea Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, 03312, South Korea
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, 361003, China
The First Affilliated Hospital of Kunming Medical University
RECRUITING

Kunming, Yunnan, 650032, China
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, 330008, China
The Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, 215004, China
The Second Affiliated Hospital of Xi'an Jiao Tong University
RECRUITING

Xi'an, 710004, China
The University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
Toronto Immune and Digestive Health Institute
RECRUITING

North YORK, Ontario, M6A 3B4, Canada
UZ Brussel
RECRUITING

Brussels, 1090, Belgium
University Gastroenterology
RECRUITING

Providence, Rhode Island, 02904, United States
University Physicians and Surgeons Inc, dba Marshall Health
RECRUITING

Huntington, West Virginia, 25701, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Massachusetts Memorial Medical Center
RECRUITING

North Worcester, Massachusetts, 01655, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Texas Health Center at Tyler
RECRUITING

Tyler, Texas, 75708, United States
University of Texas Southwestern Medical Center - Multidisciplinary Spine Clinic - James W. Aston Ambulatory Care Center
RECRUITING

Dallas, Texas, 75390-8565, United States
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Va Heartland Network - Harry S. Truman Memorial Veterans' Hospital
RECRUITING

Columbia, Missouri, 65201-5275, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212-1375, United States
Vas-Oxy Egeszsegugyi Kft
RECRUITING

Szombathely, 9700, Hungary
Virtua Crohns and Colitis Center
RECRUITING

Moorestown, New Jersey, 08057, United States
Vivamed Spolka Z Ograniczona Odpowiedzialnoscia
RECRUITING

Warsaw, 03-580, Poland
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RECRUITING

Shanghai, 200092, China
Yashoda Hospitals
RECRUITING

Secunderabad, Telangana, 500003, India
Yeungnam University Medical Center
RECRUITING

Daegu, 42415, South Korea
Zhujiang Hospital, Southern Medical University
RECRUITING

Guangzhou, 510280, China
Észak-Pesti Centrumkórház-Honvédkórház
RECRUITING

Budapest, 1062, Hungary

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