Crohn disease

This study tests an experimental drug called RO7790121 in about 21 adults with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if the drug can reduce gut inflammation and improve symptoms like diarrhea and stomach pain. Partic…

This study tests whether giving vedolizumab every 4 weeks instead of every 8 weeks can help Japanese patients with moderate to severe ulcerative colitis or Crohn's disease whose symptoms returned during standard treatment. About 56 participants will receive the drug intravenously…

This phase 2b study tests whether combining two biologic drugs, guselkumab and golimumab, works better than either drug alone for people with moderate to severe Crohn's disease. About 703 participants will receive the combination or a placebo over 48 weeks. The goal is to see if …

This large study tests whether guselkumab, an injected drug, can control symptoms and heal the gut lining in people with moderate to severe Crohn's disease. About 1,400 participants will receive guselkumab, an existing treatment (ustekinumab), or a placebo. The goal is to see if …

This study tests whether guselkumab, given as a shot under the skin, can help people with moderate to severe Crohn's disease achieve remission and heal their gut lining. About 350 adults who have not responded well to other treatments will receive either guselkumab or a placebo. …

This study tests a drug called guselkumab in 120 people with Crohn's disease to see if it can heal all layers of the digestive tract. The main goal is to check healing using an MRI scan after 48 weeks of treatment. Participants must have active Crohn's disease and will receive th…

This study follows 159 children aged 2 to 17 who have already completed a prior ustekinumab study for Crohn's disease, ulcerative colitis, or psoriatic arthritis. The goal is to collect long-term safety data by monitoring side effects, lab results, and injection-site reactions. P…

This study tests a drug called guselkumab in people with Crohn's disease who have abnormal tunnels (fistulas) near the anus. The goal is to see if the drug can close these fistulas and prevent new ones, using MRI scans to confirm healing. About 288 adults who have not responded t…

This study tests an experimental drug called AZD7798 in 24 adults with active Crohn's disease who have an ileostomy. The goal is to see if the drug is safe and can help repair the gut lining compared to a placebo. Participants will be monitored for side effects and changes in the…

This study tests a new drug called AZD7798 in 120 people with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms and improve the appearance of the gut lining. Participants are randomly assigned to receive either the drug or a placebo, and neither the…

This study looks at whether people with Crohn's disease who are in remission can safely stop taking aminosalicylate (5-ASA) medication without their condition getting worse. About 334 participants will either continue or stop their 5-ASA therapy and be followed for 2 years to see…

This study looks at the long-term safety and effectiveness of balinatunfib, an oral tablet, in adults with Crohn's disease or ulcerative colitis. Participants have already completed a one-year treatment in a previous study. The trial will last up to 107 weeks and includes both do…

This study tests two different doses of TEV-48574 (duvakitug) given as a shot every 4 weeks to adults with moderate to severe ulcerative colitis or Crohn's disease. Participants who completed a previous 14-week study can join. The goal is to see if the drug can keep the disease u…

This study looks at whether using just one medication (infliximab) under the skin works as well as using it together with another immune-suppressing drug for people with Crohn's disease or ulcerative colitis. About 420 adults who have already started infliximab will be followed f…

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study tests a support program for teens aged 16-17.5 with Crohn's disease or ulcerative colitis as they move from pediatric to adult healthcare. The program includes personalized assessments, a transition navigator, and virtual skill-building sessions. Researchers will measu…

This study looks at whether the probiotic VSL#3 can change how bile acids work in people with Crohn's disease or ulcerative colitis. About 79 participants will take two sachets of VSL#3 daily for six weeks. Researchers will measure bile acid levels in blood and stool to see if th…

This study tests whether a special anti-inflammatory diet, adapted to include traditional Puerto Rican foods, can help people with Crohn's disease feel better and reduce gut inflammation. About 150 adults with mild to moderate Crohn's will follow either the diet or their usual ea…

This study aimed to test whether injecting stem cells from a donor's bone marrow into the pouch (a surgically created internal reservoir) could safely treat pouchitis that hadn't improved with antibiotics or other drugs. The trial was planned for 12 adults aged 18-75 in the U.S.,…

This study tests whether a fecal transplant (FMT) can safely and effectively treat recurrent C. difficile infections in children, including those with inflammatory bowel disease (IBD). Researchers will give FMT to 250 children aged 3-21 and track whether the infection comes back.…

This study aimed to test whether injecting donor stem cells directly into fistulas could safely help heal them in people with Crohn's disease who have an ileal pouch. The trial was withdrawn before any participants were enrolled, so no results are available. The approach was expe…

This study tests whether risankizumab works better than ustekinumab for adults with moderate to severe Crohn's disease who have not responded to anti-TNF therapy. About 527 participants will receive either drug through IV and then injections over nearly a year, with some continui…

This phase 3 trial tests whether upadacitinib (RINVOQ), a daily oral medication, can help adults with Crohn's disease maintain remission after initial treatment. About 747 participants who responded to upadacitinib in earlier studies will receive either the drug or a placebo. The…

This early-stage trial is testing a new drug called GSK4528287 for the first time in humans. The goal is to check for side effects and see how the drug behaves in the body. 48 healthy volunteers will receive a single dose, with the amount increased gradually in different groups. …

This study tests whether injecting a person's own processed fat tissue can heal complex anal fistulas caused by Crohn's disease that have not responded to standard treatments. About 80 adults with Crohn's and active fistulas will receive either the fat injection plus standard car…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This pilot study tests whether a plant-based resistant starch, tailored to each child's gut bacteria, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. Participants will take the starch or a placebo for a period, and researchers will measure change…

This early-stage trial aimed to see if injecting donor stem cells around fistulas (abnormal tunnels) could safely help heal them in people with Crohn's disease. The study planned to enroll 20 adults with complex or multiple fistulas. However, the trial was withdrawn before any pa…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. The goal is to see if this can help maintain remission and reduce the need for stronger medication. The study involves 45 children aged 8…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This study tests whether injecting a patient's own platelet-rich plasma (PRP) into the colon after balloon dilation can prevent the colon from narrowing again in people with Crohn's disease. About 74 participants will receive either a high or low concentration of PRP during the p…

This study tests a specially selected probiotic (LR607) in 300 people with mild-to-moderate ulcerative colitis, a form of inflammatory bowel disease. The probiotic is designed to boost a natural gut pathway (NOD2) that helps control inflammation. The goal is to see if adding LR60…

This study is a survey of 335 people with moderate to severe Crohn's disease who are taking Entyvio (vedolizumab) as part of their regular care. The goal is to see how safe and effective the drug is over the long term in everyday medical practice. Researchers will track side effe…

This study looks at how well and how safely the drug mirikizumab works over the long term for people with Crohn's disease. About 996 adults who were in earlier mirikizumab studies will continue treatment. The goal is to see if the drug can keep the gut healed and symptoms under c…

This study tests an experimental drug called AGMB-129 in about 100 people with Crohn's disease who have painful bowel narrowing (strictures). The goal is to see if the drug is safe and can help reduce the narrowing, potentially avoiding the need for surgery. Participants receive …

This study tests two diet plans for adults with active Crohn's disease. One group follows the Crohn's Disease Exclusion Diet (CDED) with a liquid meal replacement, while the other adds dairy back early. The goal is to see if these diets can reduce symptoms and inflammation. The t…

This Phase 3 trial tests whether injecting a patient's own fat-derived stem cells, along with a glue, can close fistulas caused by Crohn's disease. 46 adults with Crohn's and at least one fistula are taking part. The main goal is to see if the fistula closes completely.

This study tests whether two special diets—the specific carbohydrate diet or an elemental (liquid) diet—can help people with active Crohn's disease or ulcerative colitis feel better. Forty adults will choose one diet and follow it for 6 weeks, while researchers track symptoms, in…

This early-phase trial is testing whether an oral herbal formula called E-B-FAHF-2 is safe and tolerable for people with mild-to-moderate Crohn's disease. Only 7 adults will take either the herbal capsule or a placebo for a short time. The goal is to see if it reduces inflammatio…

This study tests whether a high-protein oral supplement with HMB can improve muscle strength and mass in people with active Crohn's disease who also have sarcopenia (muscle loss). 44 participants will take the supplement alongside standard care. The main goal is to see if grip st…

This phase 3 trial is testing whether risankizumab (Skyrizi) can help people with moderate-to-severe Crohn's disease. About 289 adults will receive either the drug or a placebo as a shot under the skin for up to 24 weeks, followed by an open-label extension. The goal is to see if…

This study tests whether fecal microbiota transplant (FMT) capsules can help people with inflammatory bowel disease (IBD) who haven't improved on standard biologic drugs. 94 patients with mild-to-moderate Crohn's or ulcerative colitis will receive either FMT capsules plus a biolo…

This early-phase study tests whether taking CoQ10 supplements for 8 weeks can ease fatigue in people with Crohn's disease. About 60 adults with stable Crohn's will receive one of two doses, and researchers will track changes in fatigue and quality of life. The goal is to see if a…

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This study tests whether listening to jazz or reggae music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will compare two groups: one listens to mindful jazz, the other to reggae, over four weeks. The goal is to find a safe, non-addictive wa…

This study tests whether personalized exercise coaching can reduce fatigue and improve quality of life in children with inflammatory bowel disease (IBD). Seventy children will be split into two groups based on their current exercise habits and will follow a 24-week program with a…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study looks at whether acupuncture can reduce disease activity and pain in children with mild-to-moderate Crohn's disease or ulcerative colitis. About 60 kids on stable medication will receive acupuncture alongside their usual care. Researchers will measure changes in sympto…

This study looks at whether regular text message check-ins and the ability to text your IBD care team can improve disease management and quality of life. About 900 people with Crohn's disease or ulcerative colitis will take part. Some will get extra symptom surveys and texting ac…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This pilot study tests whether daily, at-home stimulation of a nerve in the ear can change brain activity in people with inflammatory bowel disease (IBD) who are in remission. Fifteen adults with Crohn's disease or ulcerative colitis will use a small device for 28 days and underg…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study follows nearly 5,000 children with Crohn's disease, ulcerative colitis, or indeterminate colitis to monitor the long-term safety of their treatments, including the drug infliximab. Researchers collect information on side effects, disease activity, and quality of life o…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study looks at how diet affects inflammation in people with Crohn's disease or ulcerative colitis (IBD). About 140 participants will either follow a Nordic-based test diet for six weeks or use a digital information tool. Researchers want to see if these approaches can reduce…

This study observes 1006 adults with ulcerative colitis or Crohn's disease in Brazil who are taking or have taken vedolizumab. Researchers will look at how long patients stay on the drug and what other treatments they used before. No new treatment is given—this is just a review o…

This study looks at 200 people with known or suspected inflammatory bowel disease (IBD). Researchers will use computers to analyze standard medical images and videos from endoscopies, biopsies, and scans. The goal is to create automated metrics that might help doctors assess IBD …

This pilot study is testing whether a deep learning algorithm can identify and score inflamed segments of the terminal ileum in MRI scans of people with Crohn's disease. Researchers will use 226 anonymized MRI scans, with radiologists first marking normal and abnormal areas. The …

This study looks back at medical records of 120 adults with Crohn's disease or ulcerative colitis who switched from intravenous to subcutaneous (under-the-skin) vedolizumab. Researchers want to see what dosing patterns doctors used and whether patients achieved remission. No new …

This study looks at how quickly risankizumab (Skyrizi) heals deep intestinal damage in people with Crohn's disease. Instead of repeated colonoscopies, researchers use intestinal ultrasound to track healing at 4 and 12 weeks. The goal is to find a simpler, more comfortable way to …

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study follows 300 children to understand how diet, gut bacteria, and Crohn's disease interact. Researchers will collect stool, blood, and tissue samples, plus daily food logs via an app. The goal is to build a personalized algorithm that predicts how diet affects inflammatio…

This 5-year observational study is following 15,000 adults and children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, in real-world clinics. Researchers are collecting data on disease patterns, treatment use, and patient outcomes to bett…

This study looks at whether continuous heart rate variability (HRV) monitoring can predict how well patients with inflammatory bowel disease (IBD) respond to biologic therapies like infliximab or vedolizumab. Researchers will track HRV in 100 patients starting treatment and compa…

This study looks at 112 people with small bowel Crohn's disease who are starting a new biologic therapy. Researchers use MRI scans and blood protein tests to see if they can predict who will achieve remission without steroids after one year. The goal is to help doctors choose the…

This study aims to understand how inflammatory bowel disease (IBD) affects patients' quality of life. Researchers will survey 385 adults with Crohn's disease or ulcerative colitis about their symptoms, emotional well-being, and social support. The goal is to identify factors that…

This early-phase study tests an experimental drug called PALI-2108 in a small group of people with fibrostenotic Crohn's disease, a condition where the gut becomes scarred and narrow. The main goal is to see how the drug affects inflammation and scarring at the molecular level by…

This observational study is following up to 500,000 adults with chronic gastrointestinal diseases like Crohn's disease, ulcerative colitis, and eosinophilic GI disease. Researchers will collect data from electronic health records and patient reports to understand how these condit…

This long-running study at Johns Hopkins aims to identify the genetic and environmental factors that cause inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers are enrolling 2,500 participants — including patients, their family members, …

This study aims to better understand inflammatory bowel disease (IBD) by collecting tissue samples from 1,100 people undergoing endoscopy or bowel surgery. Researchers will analyze gene activity, proteins, and gut microbes to learn what causes the disease. The study includes both…

This study aims to find genes that cause inflammatory bowel disease (IBD) specifically in African Americans. Researchers will collect health information and blood samples from 2,400 African Americans, both with and without IBD. No treatment is given—the goal is to better understa…

This study observes 562 adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are starting or switching to Hyrimoz®, a biosimilar of adalimumab. Researchers will track how many patients continue the treatment after 6 months and why some stop, such as …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study compares a new, faster MRI technique (diffusion-weighted) to the standard MRI for monitoring Crohn's disease. The new method does not require a contrast injection or bowel cleansing, which patients often dislike. Researchers will check if the new scan is just as good a…

This study looks at how a tool called CDPATH can help predict the risk of serious complications in people with Crohn's disease within the next three years. About 200 adults with Crohn's will use the tool to learn their risk level (low, medium, or high) and discuss treatment optio…

This study collects tissue samples from 178 adults with and without Crohn's disease to create a detailed map of gut cells. Researchers will compare cell types and activity between healthy and diseased tissue. The goal is to better understand what goes wrong in Crohn's and identif…

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This registry is following over 2,200 adults with inflammatory bowel disease (IBD) across North America to see how approved treatments work in everyday practice. Researchers are collecting data on disease patterns, complications, and patient outcomes. The goal is to better unders…

This study is collecting health information from 2,000 people with Crohn's disease or ulcerative colitis across three hospitals in South Korea. Researchers aim to build computer models that can predict how each patient will respond to different treatments. No new drugs are being …

This study follows 100 children with Crohn's disease to track their symptoms, treatments, and outcomes in everyday medical care. Researchers will look at how different therapies—like special diets, medications, or fecal transplants—affect disease activity over 14 to 54 weeks. The…